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Magnetic resonance imaging (MRI) offers superior soft tissue contrast and is widely used in biomedicine. However, conventional MRI is not quantitative, which presents a bottleneck in image analysis and digital healthcare. Typically, additional scans are required to disentangle the effect of multiple parameters of MR and extract quantitative tissue properties. Here we investigate a data-driven strategy Q^2 MRI (Qualitative and Quantitative MRI) to derive quantitative parametric maps from standard MR images without additional data acquisition. By taking advantage of the interdependency between various MRI parametric maps buried in training data, the proposed deep learning strategy enables accurate prediction of tissue relaxation properties as well as other biophysical and biochemical characteristics from a single or a few images with conventional T_1/T_2 weighting. Superior performance has been achieved in quantitative MR imaging of the knee and liver. Q^2 MRI promises to provide a powerful tool for a variety of biomedical applications and facilitate the next generation of digital medicine.
Purpose: To develop a fast magnetic resonance fingerprinting (MRF) method for quantitative chemical exchange saturation transfer (CEST) imaging. Methods: We implemented a CEST-MRF method to quantify the chemical exchange rate and volume fraction of
Obtaining magnetic resonance images (MRI) with high resolution and generating quantitative image-based biomarkers for assessing tissue biochemistry is crucial in clinical and research applications. How- ever, acquiring quantitative biomarkers require
Nuclear magnetic resonance (NMR) diffusion measurements are widely used to derive parameters indirectly related to the microstructure of biological tissues and porous media. However, a direct imaging of cell or pore shapes and sizes would be of high
Quantitative analysis of cell structures is essential for biomedical and pharmaceutical research. The standard imaging approach relies on fluorescence microscopy, where cell structures of interest are labeled by chemical staining techniques. However,
Parallel magnetic resonance imaging (MRI) is a technique of image acceleration which takes advantage of the localization of the field of view (FOV) of coils in an array. In this letter we show that metamaterial lenses based on capacitively-loaded rin