اشترك بالحزمة الذهبية واحصل على وصول غير محدود شمرا أكاديميا
تسجيل مستخدم جديدLocal details versus effective medium approximation: A study of diffusion in microfluidic random networks made from Voronoi tessellations
45
0
0.0
(
0
)
اسأل ChatGPT حول البحث
ﻻ يوجد ملخص باللغة العربية
We measured the effective diffusion coefficient in regions of microfluidic networks of controlled geometry using the FRAP (Fluorescence Recovery After Photobleaching) technique. The geometry of the networks was based on Voronoi tessellations, and had varying characteristic length scale and porosity. For a fixed network, FRAP experiments were performed in regions of increasing size. Our results indicate that the boundary of the bleached region, and in particular the cumulative area of the channels that connect the bleached region to the rest of the network, are important in the measured value of the effective diffusion coefficient. We found that the statistical geometrical variations between different regions of the network decrease with the size of the bleached region as a power law, meaning that the statistical error of effective medium approximations decrease with the size of the studied medium, although no characteristic length scale could be defined over which the porous medium is equivalent to an effective medium.
قيم البحث
اقرأ أيضاً
We present a technique to locally and rapidly heat water drops in microfluidic devices with microwave dielectric heating. Water absorbs microwave power more efficiently than polymers, glass, and oils due to its permanent molecular dipole moment that
has a large dielectric loss at GHz frequencies. The relevant heat capacity of the system is a single thermally isolated picoliter drop of water and this enables very fast thermal cycling. We demonstrate microwave dielectric heating in a microfluidic device that integrates a flow-focusing drop maker, drop splitters, and metal electrodes to locally deliver microwave power from an inexpensive, commercially available 3.0 GHz source and amplifier. The temperature of the drops is measured by observing the temperature dependent fluorescence intensity of cadmium selenide nanocrystals suspended in the water drops. We demonstrate characteristic heating times as short as 15 ms to steady-state temperatures as large as 30 degrees C above the base temperature of the microfluidic device. Many common biological and chemical applications require rapid and local control of temperature, such as PCR amplification of DNA, and can benefit from this new technique.
In this paper, we construct a new family of random series defined on $R^D$, indexed by one scaling parameter and two Hurst-like exponents. The model is close to Takagi-Knopp functions, save for the fact that the underlying partitions of $R^D$ are not
the usual dyadic meshes but random Voronoi tessellations generated by Poisson point processes. This approach leads us to a continuous function whose random graph is shown to be fractal with explicit and equal box and Hausdorff dimensions. The proof of this main result is based on several new distributional properties of the Poisson-Voronoi tessellation on the one hand, an estimate of the oscillations of the function coupled with an application of a Frostman-type lemma on the other hand. Finally, we introduce two related models and provide in particular a box-dimension calculation for a derived deterministic Takagi-Knopp series with hexagonal bases.
A biomimetic model of cell-cell communication was developed to probe the passive molecular transport across ion channels inserted in synthetic lipid bilayers formed between contacting droplets arranged in a linear array. Diffusion of a fluorescent pr
obe across the array was measured for different pore concentrations. The diffusion characteristic time scale is found to vary non-linearly with the pore concentration. Our measurements are successfully modeled by a continuous time random walk description, whose waiting time is the first exit time from a droplet through a cluster of pores. The size of the cluster of pores is found to increase with their concentration. Our results provide a direct link between the mesoscopic permeation properties and the microscopic characteristics of the pores such as their number, size and spatial arrangement.
The problem of the time required for a diffusing molecule, within a large bounded domain, to first locate a small target is prevalent in biological modeling. Here we study this problem for a small spherical target. We develop uniform in time asymptot
ic expansions in the target radius of the solution to the corresponding diffusion equation. Our approach is based on combining short-time expansions using pseudo-potential approximations with long-time expansions based on first eigenvalue and eigenfunction approximations. These expansions allow the calculation of corresponding expansions of the first passage time density for the diffusing molecule to find the target. We demonstrate the accuracy of our method in approximating the first passage time density and related statistics for the spherically symmetric problem where the domain is a large concentric sphere about a small target centered at the origin.
Determining the masses of new physics particles appearing in decay chains is an important and longstanding problem in high energy phenomenology. Recently it has been shown that these mass measurements can be improved by utilizing the boundary of the
allowed region in the fully differentiable phase space in its full dimensionality. Here we show that the practical challenge of identifying this boundary can be solved using techniques based on the geometric properties of the cells resulting from Voronoi tessellations of the relevant data. The robust detection of such phase space boundaries in the data could also be used to corroborate a new physics discovery based on a cut-and-count analysis.
سجل دخول لتتمكن من نشر تعليقات
التعليقات
جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
