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Model selection based on experimental data is an important challenge in biological data science. Particularly when collecting data is expensive or time consuming, as it is often the case with clinical trial and biomolecular experiments, the problem of selecting information-rich data becomes crucial for creating relevant models. We identify geometric properties of input data that result in a unique algebraic model and we show that if the data form a staircase, or a so-called linear shift of a staircase, the ideal of the points has a unique reduced Gro bner basis and thus corresponds to a unique model. We use linear shifts to partition data into equivalence classes with the same basis. We demonstrate the utility of the results by applying them to a Boolean model of the well-studied lac operon in E. coli.
In the field of algebraic systems biology, the number of minimal polynomial models constructed using discretized data from an underlying system is related to the number of distinct reduced Grobner bases for the ideal of the data points. While the the
In this paper, we make a contribution to the computation of Grobner bases. For polynomial reduction, instead of choosing the leading monomial of a polynomial as the monomial with respect to which the reduction process is carried out, we investigate w
In this work we provide a definition of a coloured operad as a monoid in some monoidal category, and develop the machinery of Grobner bases for coloured operads. Among the examples for which we show the existance of a quadratic Grobner basis we con
Grassmann manifolds $G_{k,n}$ are among the central objects in geometry and topology. The Borel picture of the mod 2 cohomology of $G_{k,n}$ is given as a polynomial algebra modulo a certain ideal $I_{k,n}$. The purpose of this paper is to understand
The universal Gr{o}bner basis of $I$, is a Gr{o}bner basis for $I$ with respect to all term orders simultaneously. Let $I_G$ be the toric ideal of a graph $G$. We characterize in graph theoretical terms the elements of the universal Gr{o}bner basis o