ترغب بنشر مسار تعليمي؟ اضغط هنا

Control of epidemics via social partnership adjustment

277   0   0.0 ( 0 )
 نشر من قبل Da Zhou Dr.
 تاريخ النشر 2016
  مجال البحث علم الأحياء فيزياء
والبحث باللغة English




اسأل ChatGPT حول البحث

Epidemic control is of great importance for human society. Adjusting interacting partners is an effective individualized control strategy. Intuitively, it is done either by shortening the interaction time between susceptible and infected individuals or by increasing the opportunities for contact between susceptible individuals. Here, we provide a comparative study on these two control strategies by establishing an epidemic model with non-uniform stochastic interactions. It seems that the two strategies should be similar, since shortening the interaction time between susceptible and infected individuals somehow increases the chances for contact between susceptible individuals. However, analytical results indicate that the effectiveness of the former strategy sensitively depends on the infectious intensity and the combinations of different interaction rates, whereas the latter one is quite robust and efficient. Simulations are shown in comparison with our analytical predictions. Our work may shed light on the strategic choice of disease control.



قيم البحث

اقرأ أيضاً

The interpretation of sampling data plays a crucial role in policy response to the spread of a disease during an epidemic, such as the COVID-19 epidemic of 2020. However, this is a non-trivial endeavor due to the complexity of real world conditions a nd limits to the availability of diagnostic tests, which necessitate a bias in testing favoring symptomatic individuals. A thorough understanding of sampling confidence and bias is necessary in order make accurate conclusions. In this manuscript, we provide a stochastic model of sampling for assessing confidence in disease metrics such as trend detection, peak detection, and disease spread estimation. Our model simulates testing for a disease in an epidemic with known dynamics, allowing us to use Monte-Carlo sampling to assess metric confidence. This model can provide realistic simulated data which can be used in the design and calibration of data analysis and prediction methods. As an example, we use this method to show that trends in the disease may be identified using under $10000$ biased samples each day, and an estimate of disease spread can be made with additional $1000-2000$ unbiased samples each day. We also demonstrate that the model can be used to assess more advanced metrics by finding the precision and recall of a strategy for finding peaks in the dynamics.
Human mobility is a key component of large-scale spatial-transmission models of infectious diseases. Correctly modeling and quantifying human mobility is critical for improving epidemic control policies, but may be hindered by incomplete data in some regions of the world. Here we explore the opportunity of using proxy data or models for individual mobility to describe commuting movements and predict the diffusion of infectious disease. We consider three European countries and the corresponding commuting networks at different resolution scales obtained from official census surveys, from proxy data for human mobility extracted from mobile phone call records, and from the radiation model calibrated with census data. Metapopulation models defined on the three countries and integrating the different mobility layers are compared in terms of epidemic observables. We show that commuting networks from mobile phone data well capture the empirical commuting patterns, accounting for more than 87% of the total fluxes. The distributions of commuting fluxes per link from both sources of data - mobile phones and census - are similar and highly correlated, however a systematic overestimation of commuting traffic in the mobile phone data is observed. This leads to epidemics that spread faster than on census commuting networks, however preserving the order of infection of newly infected locations. Match in the epidemic invasion pattern is sensitive to initial conditions: the radiation model shows higher accuracy with respect to mobile phone data when the seed is central in the network, while the mobile phone proxy performs better for epidemics seeded in peripheral locations. Results suggest that different proxies can be used to approximate commuting patterns across different resolution scales in spatial epidemic simulations, in light of the desired accuracy in the epidemic outcome under study.
Mathematical disease modelling has long operated under the assumption that any one infectious disease is caused by one transmissible pathogen spreading among a population. This paradigm has been useful in simplifying the biological reality of epidemi cs and has allowed the modelling community to focus on the complexity of other factors such as population structure and interventions. However, there is an increasing amount of evidence that the strain diversity of pathogens, and their interplay with the host immune system, can play a large role in shaping the dynamics of epidemics. Here, we introduce a disease model with an underlying genotype network to account for two important mechanisms. One, the disease can mutate along network pathways as it spreads in a host population. Two, the genotype network allows us to define a genetic distance across strains and therefore to model the transcendence of immunity often observed in real world pathogens. We study the emergence of epidemics in this model, through its epidemic phase transitions, and highlight the role of the genotype network in driving cyclicity of diseases, large scale fluctuations, sequential epidemic transitions, as well as localization around specific strains of the associated pathogen. More generally, our model illustrates the richness of behaviours that are possible even in well-mixed host populations once we consider strain diversity and go beyond the one disease equals one pathogen paradigm.
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic threatens the health of humans and causes great economic losses. Predictive modelling and forecasting the epidemic trends are essential for developing countermeasures to mitigate this pandemic. We develop a network model, where each node represents an individual and the edges represent contacts between individuals where the infection can spread. The individuals are classified based on the number of contacts they have each day (their node degrees) and their infection status. The transmission network model was respectively fitted to the reported data for the COVID-19 epidemic in Wuhan (China), Toronto (Canada), and the Italian Republic using a Markov Chain Monte Carlo (MCMC) optimization algorithm. Our model fits all three regions well with narrow confidence intervals and could be adapted to simulate other megacities or regions. The model projections on the role of containment strategies can help inform public health authorities to plan control measures.
Cooperative behaviour constitutes a key aspect of both human society and non-human animal systems, but explaining how cooperation evolves represents a major scientific challenge. It is now well established that social network structure plays a centra l role for the viability of cooperation. However, not much is known about the importance of the positions of cooperators in the networks for the evolution of cooperation. Here, we investigate how cooperation is affected by correlations between cooperativeness and individual social connectedness. Using simulation models, we find that the effect of correlation between cooperativeness and connectedness (degree) depends on the social network structure, with positive effect in standard scale-free networks and no effect in standard Poisson networks. Furthermore, when degree assortativity is increased such that individuals cluster with others of similar social connectedness, we find that bridge areas between social clusters can act as barriers to the spread of defection, leading to strong enhancement of cooperation in particular in Poisson networks. But this effect is sensitive to the presence of Trojan horses (defectors placed within cooperator clusters). The study provides new knowledge about the conditions under which cooperation may evolve and persist, and the results are also relevant to consider in regard to human cooperation experiments.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا