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Register a new userThematic analysis of multiple sclerosis research by enhanced strategic diagram
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This bibliometric review summarised the research trends and analysed research areas in multiple sclerosis (MS) over the last decade. The documents containing the term multiple sclerosis in the article title were retrieved from the Scopus database. We found a total of 18003 articles published in journals in the English language between 2012 and 2021. The emerging keywords identified utilising the enhanced strategic diagram were covid-19, teriflunomide, clinical trial, microglia, b cells, myelin, brain, white matter, functional connectivity, pain, employment, health-related quality of life, meta-analysis and comorbidity. In conclusion, this study demonstrates the tremendous growth of MS literature worldwide, which is expected to grow more than double during the next decade especially in the identified emerging topics.
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Automated classification of metadata of research data by their discipline(s) of research can be used in scientometric research, by repository service providers, and in the context of research data aggregation services. Openly available metadata of the DataCite index for research data were used to compile a large training and evaluation set comprised of 609,524 records, which is published alongside this paper. These data allow to reproducibly assess classification approaches, such as tree-based models and neural networks. According to our experiments with 20 base classes (multi-label classification), multi-layer perceptron models perform best with a f1-macro score of 0.760 closely followed by Long Short-Term Memory models (f1-macro score of 0.755). A possible application of the trained classification models is the quantitative analysis of trends towards interdisciplinarity of digital scholarly output or the characterization of growth patterns of research data, stratified by discipline of research. Both applications perform at scale with the proposed models which are available for re-use.
One of the main challenges for biomedical research lies in the computer-assisted integrative study of large and increasingly complex combinations of data in order to understand molecular mechanisms. The preservation of the materials and methods of such computational experiments with clear annotations is essential for understanding an experiment, and this is increasingly recognized in the bioinformatics community. Our assumption is that offering means of digital, structured aggregation and annotation of the objects of an experiment will provide necessary meta-data for a scientist to understand and recreate the results of an experiment. To support this we explored a model for the semantic description of a workflow-centric Research Object (RO), where an RO is defined as a resource that aggregates other resources, e.g., datasets, software, spreadsheets, text, etc. We applied this model to a case study where we analysed human metabolite variation by workflows.
Even as we advance the frontiers of physics knowledge, our understanding of how this knowledge evolves remains at the descriptive levels of Popper and Kuhn. Using the APS publications data sets, we ask in this letter how new knowledge is built upon old knowledge. We do so by constructing year-to-year bibliographic coupling networks, and identify in them validated communities that represent different research fields. We then visualize their evolutionary relationships in the form of alluvial diagrams, and show how they remain intact through APS journal splits. Quantitatively, we see that most fields undergo weak Popperian mixing, and it is rare for a field to remain isolated/undergo strong mixing. The sizes of fields obey a simple linear growth with recombination. We can also reliably predict the merging between two fields, but not for the considerably more complex splitting. Finally, we report a case study of two fields that underwent repeated merging and splitting around 1995, and how these Kuhnian events are correlated with breakthroughs on BEC, quantum teleportation, and slow light. This impact showed up quantitatively in the citations of the BEC field as a larger proportion of references from during and shortly after these events.
Recent advances in neuroscience data acquisition allow for the simultaneous recording of large populations of neurons across multiple brain areas while subjects perform complex cognitive tasks. Interpreting these data requires us to index how task-relevant information is shared across brain regions, but this is often confounded by the mixing of different task parameters at the single neuron level. Here, inspired by a method developed for a single brain area, we introduce a new technique for demixing variables across multiple brain areas, called demixed shared component analysis (dSCA). dSCA decomposes population activity into a few components, such that the shared components capture the maximum amount of shared information across brain regions while also depending on relevant task parameters. This yields interpretable components that express which variables are shared between different brain regions and when this information is shared across time. To illustrate our method, we reanalyze two datasets recorded during decision-making tasks in rodents and macaques. We find that dSCA provides new insights into the shared computation between different brain areas in these datasets, relating to several different aspects of decision formation.
Research grants have played an important role in seeding and promoting fundamental research projects worldwide. There is a growing demand for developing and delivering scientific influence analysis as a service on research grant repositories. Such analysis can provide insight on how research grants help foster new research collaborations, encourage cross-organizational collaborations, influence new research trends, and identify technical leadership. This paper presents the design and development of a grants-based scientific influence analysis service, coined as GImpact. It takes a graph-theoretic approach to design and develop large scale scientific influence analysis over a large research-grant repository with three original contributions. First, we mine the grant database to identify and extract important features for grants influence analysis and represent such features using graph theoretic models. For example, we extract an institution graph and multiple associated aspect-based collaboration graphs, including a discipline graph and a keyword graph. Second, we introduce self-influence and co-influence algorithms to compute two types of collaboration relationship scores based on the number of grants and the types of grants for institutions. We compute the self-influence scores to reflect the grant based research collaborations among institutions and compute multiple co-influence scores to model the various types of cross-institution collaboration relationships in terms of disciplines and subject areas. Third, we compute the overall scientific influence score for every pair of institutions by introducing a weighted sum of the self-influence score and the multiple co-influence scores and conduct an influence-based clustering analysis. We evaluate GImpact using a real grant database, consisting of 2512 institutions and their grants received over a period of 14 years...
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