Most existing NER methods rely on extensive labeled data for model training, which struggles in the low-resource scenarios with limited training data. Recently, prompt-tuning methods for pre-trained language models have achieved remarkable performance in few-shot learning by exploiting prompts as task guidance to reduce the gap between training progress and downstream tuning. Inspired by prompt learning, we propose a novel lightweight generative framework with prompt-guided attention for low-resource NER (LightNER). Specifically, we construct the semantic-aware answer space of entity categories for prompt learning to generate the entity span sequence and entity categories without any label-specific classifiers. We further propose prompt-guided attention by incorporating continuous prompts into the self-attention layer to re-modulate the attention and adapt pre-trained weights. Note that we only tune those continuous prompts with the whole parameter of the pre-trained language model fixed, thus, making our approach lightweight and flexible for low-resource scenarios and can better transfer knowledge across domains. Experimental results show that LightNER can obtain comparable performance in the standard supervised setting and outperform strong baselines in low-resource settings by tuning only a small part of the parameters.