The neighborhood complex of a graph was introduced by Lovasz to provide topological lower bounds on chromatic number, and more general homomorphism complexes of graphs were further studied by Babson and Kozlov. Such `Hom complexes are also related to reconfiguration problems and a notion of discrete homotopy for graphs. Here we initiate the detailed study of Hom complexes for directed graphs, which have applications in the study of graded posets and resolutions of monomial ideals. Our construction can be seen as a special case of the poset structure on the set of multihomomorphisms in more general categories, as introduced by Kozlov, Matsushita, and others. We relate the topological properties of Hom complexes to certain digraph operations including products, adjunctions, and foldings. We introduce a notion of a neighborhood complex for a directed graph and prove that its homotopy type is recovered as a certain Hom complex. We establish a number of results regarding the topology of these complexes, including the dependence on directed bipartite subgraphs, a directed version of the Mycielksi construction, as well as vanishing theorems for higher homology. Inspired by notions of reconfigurations of directed graph colorings we study the connectivity of Hom complexes into tournaments $T_n$. We obtain a complete answer for the case of transitive $T_n$, where we also describe a connection to mixed subdivisions of dilated simplices. Finally we use paths in the internal hom objects of directed graphs to define various notions of homotopy, and discuss connections to the topology of Hom complexes.