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Register a new userExperimental measurement of kinetic parameters using quantum plasmonic sensing
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Kinetic models are essential for describing how molecules interact in a variety of biochemical processes. The estimation of a models kinetic parameters by experiment enables researchers to understand how pathogens, such as viruses, interact with other entities like antibodies and trial drugs. In this work, we report a proof-of-principle experiment that uses quantum sensing techniques to give a more precise estimation of kinetic parameters than is possible with a classical approach. The specific interaction we study is that of bovine serum albumin (BSA) binding to gold via an electrostatic mechanism. BSA is an important protein in biochemical research as it can be conjugated with other proteins and peptides to create sensors with a wide range of specificity. We use single photons generated via parametric down-conversion to probe the BSA-gold interaction in a plasmonic resonance sensor. We find that sub-shot-noise level fluctuations in the sensor signal allow us to achieve an improvement in the precision of up to 31.8% for the values of the kinetic parameters. This enhancement can in principle be further increased in the setup. Our work highlights the potential use of quantum states of light for sensing in biochemical research.
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The measurement of parameters that describe kinetic processes is important in the study of molecular interactions. It enables a deeper understanding of the physical mechanisms underlying how different biological entities interact with each other, such as viruses with cells, vaccines with antibodies, or new drugs with specific diseases. In this work, we study theoretically the use of quantum sensing techniques for measuring the kinetic parameters of molecular interactions. The sensor we consider is a plasmonic resonance sensor -- a label-free photonic sensor that is one of the most widely used in research and industry. The first type of interaction we study is the antigen BSA interacting with antibody IgG1, which provides a large sensor response. The second type is the enzyme carbonic anhydrase interacting with the tumor growth inhibitor benzenesulfonamide, which produces a small sensor response. For both types of interaction we consider the use of two-mode Fock states, squeezed vacuum states and squeezed displaced states. We find that these quantum states offer an enhancement in the measurement precision of kinetic parameters when compared to that obtained with classical light. The results may help in the design of more precise quantum-based sensors for studying kinetics in the life sciences.
Quantum resources can enhance the sensitivity of a device beyond the classical shot noise limit and, as a result, revolutionize the field of metrology through the development of quantum-enhanced sensors. In particular, plasmonic sensors, which are widely used in biological and chemical sensing applications, offer a unique opportunity to bring such an enhancement to real-life devices. Here, we use bright entangled twin beams to enhance the sensitivity of a plasmonic sensor used to measure local changes in refractive index. We demonstrate a 56% quantum enhancement in the sensitivity of state-of-the-art plasmonic sensor with measured sensitivities on the order of $10^{-10}$RIU$/sqrt{textrm{Hz}}$, nearly 5 orders of magnitude better than previous proof-of-principle implementations of quantum-enhanced plasmonic sensors. These results promise significant enhancements in ultratrace label free plasmonic sensing and will find their way into areas ranging from biomedical applications to chemical detection.
Photonic sensors have many applications in a range of physical settings, from measuring mechanical pressure in manufacturing to detecting protein concentration in biomedical samples. A variety of sensing approaches exist, and plasmonic systems in particular have received much attention due to their ability to confine light below the diffraction limit, greatly enhancing sensitivity. Recently, quantum techniques have been identified that can outperform classical sensing methods and achieve sensitivity below the so-called shot-noise limit. Despite this significant potential, the use of definite photon number states in lossy plasmonic systems for further improving sensing capabilities is not well studied. Here, we investigate the sensing performance of a plasmonic interferometer that simultaneously exploits the quantum nature of light and its electromagnetic field confinement. We show that, despite the presence of loss, specialised quantum resources can provide improved sensitivity and resolution beyond the shot-noise limit within a compact plasmonic device operating below the diffraction limit.
The time-symmetric formalism endows the weak measurement and its outcome, the weak value, many unique features. In particular, it allows a direct tomography of quantum states without resort to complicated reconstruction algorithms and provides an operational meaning to wave functions and density matrices. To date the direct tomography only takes the forward direction of the weak measurement. Here we propose the direct tomography of a measurement apparatus by combining the backward direction of weak measurement and retrodictive description of quantum measurement. As an experimental demonstration, the scheme is applied to the characterization of both projective measurements and general positive operator-valued measures with a photonic setup. Our work provides new insight on the symmetry between quantum states and measurements, as well as an efficient method to characterize a measurement apparatus.
We propose a direct and real-time ranging scheme using an optical frequency combs, able to compensate optically for index of refraction variations due to atmospheric parameters. This scheme could be useful for applications requiring stringent precision over a long distance in air, a situation where dispersion becomes the main limitation. The key ingredient is the use of a mode-locked laser as a precise source for multi-wavelength interferometry in a homodyne detection scheme. By shaping temporally the local oscillator, one can directly access the desired parameter (distance) while being insensitive to fluctuations induced by parameters of the environment such as pressure, temperature, humidity and CO$_2$ content.
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