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A new distance based on minimal absent words and applications to biological sequences

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 Publication date 2021
and research's language is English




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A minimal absent word of a sequence x, is a sequence yt hat is not a factorof x, but all of its proper factors are factors of x as well. The set of minimal absent words uniquely defines the sequence itself. In recent times minimal absent words have been used in order to compare sequences. In fact, to do this, one can compare the sets of their minimal absent words. Chairungasee and Crochemorein [2] define a distance between pairs of sequences x and y, where the symmetric difference of the sets of minimal absent words of x and y is involved. Here, weconsider a different distance, introduced in [1], based on a specific subset of such symmetric difference that, in our opinion, better capture the different features ofthe considered sequences. We show the result of some experiments where the distance is tested on a dataset of genetic sequences by 11 living species, in order to compare the new distance with the ones existing in literature.



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Minimal forbidden factors are a useful tool for investigating properties of words and languages. Two factorial languages are distinct if and only if they have different (antifactorial) sets of minimal forbidden factors. There exist algorithms for computing the minimal forbidden factors of a word, as well as of a regular factorial language. Conversely, Crochemore et al. [IPL, 1998] gave an algorithm that, given the trie recognizing a finite antifactorial language $M$, computes a DFA recognizing the language whose set of minimal forbidden factors is $M$. In the same paper, they showed that the obtained DFA is minimal if the input trie recognizes the minimal forbidden factors of a single word. We generalize this result to the case of a circular word. We discuss several combinatorial properties of the minimal forbidden factors of a circular word. As a byproduct, we obtain a formal definition of the factor automaton of a circular word. Finally, we investigate the case of minimal forbidden factors of the circular Fibonacci words.
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