The interplay between non-Hermiticity and topology opens an exciting avenue for engineering novel topological matter with unprecedented properties. While previous studies have mainly focused on one-dimensional systems or Chern insulators, here we investigate topological phase transitions to/from quantum spin Hall (QSH) insulators driven by non-Hermiticity. We show that a trivial to QSH insulator phase transition can be induced by solely varying non-Hermitian terms, and there exists exceptional edge arcs in QSH phases. We establish two topological invariants for characterizing the non-Hermitian phase transitions: i) with time-reversal symmetry, the biorthogonal $mathbb{Z}_2$ invariant based on non-Hermitian Wilson loops, and ii) without time-reversal symmetry, a biorthogonal spin Chern number through biorthogonal decompositions of the Bloch bundle of the occupied bands. These topological invariants can be applied to a wide class of non-Hermitian topological phases beyond Chern classes, and provides a powerful tool for exploring novel non-Hermitian topological matter and their device applications.