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Register a new userKeratoconus Recognition Using A Parameter Set Determined from IOP-Matched Scenario
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PURPOSE: Among the current practices for keratoconus recognition using biomechanical parameters from Corvis ST, matching intra-ocular pressure (IOP) is often required to eliminate the biasing influence; as a result, the combined biomechanical parameters determined from IOP-unmatched scenario possibly bring in confounding influence. This paper was therefore designed to introduce a novel compatible parameter set (CPS) determined from IOP-matched scenario, hopefully could show its compatibility and superiority for recognizing keratoconus in both IOP-matched and not scenarios. METHODS: A total of 335 eyes were included. Among them, 70 eyes were used to determined CPS by forward logistics regression, 62 eyes were used to validate CPS in IOP-matched scenario, and resting 203 eyes were used to validate CPS in IOP-unmatched scenario. To analyze its superiority, CPS was also compared with other two reported Biomechanical Indexes (aCBI and DCR) in both scenarios. Receiver operating characteristic curves (ROC), accuracy, FI, sensitivity and specificity were used to access and compare the performance of these three parameter sets in both scenarios. RESULTS: The resulting CPS was comprised of only 3 biomechanical parameters: DA Ratio Max 1mm (DRM1), the first applanation time (AT1) and an energy loading parameter (Eload). In the IOP-matched validation, the area under ROC (AUC) reached 95.73%, with an accuracy of 95.2%, sensitivity of 93.5% and specificity of 96.8% (leave one out cross-validation). All these indicators reached 96.54%, 95.1%, 95.6% and 94.6% respectively, in the IOP-unmatched validation (leave one out cross-validation). Surprisingly, CPS performed better than other two parameter sets on a whole. CONCLUSIONS: The parameter set determined from IOP-matched scenario indeed exhibit its superiority for differentiation of keratoconus and normal corneas, regardless of IOP-matched or not.
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Purpose: This study aimed to investigate the actual changes of central corneal thickness (CCT) in keratoconus and normal corneas during air puff indentation, by using corneal visualization Scheimpflug technology (Corvis ST). Methods: A total of 32 keratoconic eyes and 46 normal eyes were included in this study. Three parameters of CCTinitial, CCTfinal and CCTpeak were selected to represent the CCT at initial time, final time and highest corneal concavity, respectively, during air puff indentation. Wilcoxon signed rank test (paired sample test) was used to assess the differences between these 3 parameters in both keratoconus and normal groups. Univariate linear regression analysis was performed to determine the effect of CCTinitial on CCTpeak and CCTfinal, as well as the impact of air puff force on CCT in each group. Receiver operating characteristic (ROC) curves were constructed to evaluate the discriminative ability of the 3 parameters. Results: The results demonstrated that CCTpeak and CCTfinal were significantly decreased (p<0.01) compared to CCTinitial in both keratoconus and normal groups. Regression analysis indicated a significant positive correlation between CCTpeak and CCTinitial in normal cornea group (R2=0.337, p<0.01), but not in keratoconus group (R2=0.029, p=0.187). Likewise, regression models of air puff force and CCT revealed the different patterns of CCT changes between keratoconus and normal cornea groups. Furthermore, ROC curves showed that CCTpeak exhibited the greatest AUC (area under ROC curve) of 0.940, with accuracy, sensitivity and specificity of 94.9%, 87.5% and 100%, respectively. Conclusions: CCT may change during air puff indentation, and is significantly different between keratoconus and normal cornea groups. The changing pattern is useful for the diagnosis of keratoconus, and lays the foundation for corneal biomechanics.
We present two sets of 12 integers that have the same sets of 4-sums. The proof of the fact that a set of 12 numbers is uniquely determined by the set of its 4-sums published 50 years ago is wrong, and we demonstrate an incorrect calculation in it.
Face recognition has been one of the most relevant and explored fields of Biometrics. In real-world applications, face recognition methods usually must deal with scenarios where not all probe individuals were seen during the training phase (open-set scenarios). Therefore, open-set face recognition is a subject of increasing interest as it deals with identifying individuals in a space where not all faces are known in advance. This is useful in several applications, such as access authentication, on which only a few individuals that have been previously enrolled in a gallery are allowed. The present work introduces a novel approach towards open-set face recognition focusing on small galleries and in enrollment detection, not identity retrieval. A Siamese Network architecture is proposed to learn a model to detect if a face probe is enrolled in the gallery based on a verification-like approach. Promising results were achieved for small galleries on experiments carried out on Pubfig83, FRGCv1 and LFW datasets. State-of-the-art methods like HFCN and HPLS were outperformed on FRGCv1. Besides, a new evaluation protocol is introduced for experiments in small galleries on LFW.
Over the past few decades, researchers have developed several approaches such as the Reference Phantom Method (RPM) to estimate ultrasound attenuation coefficient (AC) and backscatter coefficient (BSC). AC and BSC can help to discriminate pathology from normal tissue during in-vivo imaging. In this paper, we propose a new RPM model to simultaneously compute AC and BSC for harmonic imaging and a normalized score that combines the two parameters as a measure of disease progression. The model utilizes the spectral difference between two regions of interest, the first, a proximal, close to the probe and second, a distal, away from the probe. We have implemented an algorithm based on the model and shown that it provides accurate and stable estimates to within 5% of AC and BSC for simulated received echo from post-focal depths of a homogeneous liver-like medium. For practical applications with time gain and time frequency compensated in-phase and quadrature (IQ) data from ultrasound scanner, the method has been approximated and generalized to estimate AC and BSC for tissue layer underlying a more attenuative subcutaneous layer. The angular spectrum approach for ultrasound propagation in biological tissue is employed as a virtual Reference Phantom (VRP). The VRP is calibrated with a fixed probe and scanning protocol for application to liver tissue. In a feasibility study with 16 subjects, the method is able to separate 9/11 cases of progressive non-alcoholic fatty liver disease from 5 normal. In particular, it is able to separate 4/5 cases of non-alcoholic steato-hepatitis and early fibrosis (F<=2) from normal tissue. More extensive clinical studies are needed to assess the full capability of this model for screening and monitoring disease progression in liver and other tissues.
We generalize the quantum Fisher information flow proposed by Lu textit{et al}. [Phys. Rev. A textbf{82}, 042103 (2010)] to the multi-parameter scenario from the information geometry perspective. A measure named the textit{intrinsic density flow} (IDF) is defined with the time-variation of the intrinsic density of quantum states (IDQS). IDQS measures the local distinguishability of quantum states in state manifolds. The validity of IDF is clarified with its vanishing under the parameter-independent unitary evolution and outward-flow (negativity) under the completely positive-divisible map. The temporary backflow (positivity) of IDF is thus an essential signature of the non-Markovian dynamics. Specific for the time-local master equation, the IDF decomposes according to the channels, and the positive decay rate indicates the inwards flow of the sub-IDF. As time-dependent scalar fields equipped on the state space, the distribution of IDQS and IDF comprehensively illustrates the distortion of state space induced by its environment. As example, a typical qubit model is given.
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