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Recent 3D organ reconstitution studies show that a group of stem cells can establish a body axis and acquire different fates in a spatially organized manner. How such symmetry breaking happens in the absence of external spatial cues, and how developmental circuits are built to permit this is largely unknown. Here, we review spontaneous symmetry breaking phenomena in organoids, and hypothesize underlying patterning mechanisms that involve interacting diffusible species. Recent theoretical advances offer new directions beyond the prototypical Turing model. Experiments guided by theory will allow us to predict and control organoid self-organization.
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The concept of internal anatomical asymmetry is familiar; usually in humans the heart is on the left and the liver is on the right, however how does the developing embryo know to produce this consistent laterality? Symmetry breaking initiates with left-right asymmetric cilia-driven fluid mechanics in a small fluid-filled structure called the ventral node in mice. However the question of what converts this flow into left-right asymmetric development remains unanswered. A leading hypotheses is that flow transports morphogen containing vesicles within the node, the absorption of which results in asymmetrical gene expression. To investigate how vesicle transport might result in the situs patterns observed in wildtype and mutant experiments, we extend the open source Stokes flow package, NEAREST, to consider the hydrodynamic and Brownian motion of particles in a mouse model with flow driven by one, two, and 112 beating cilia. Three models for morphogen-containing particle released are simulated to assess their compatibility with observed results in oligociliated and wildtype mouse embryos: uniformly random release, localised cilium stress induced release, and localised release from motile cilia themselves. Only the uniformly random release model appears consistent with the data, with neither localised-release model resulting in significant transport in the oligociliated embryo.
We show how translational invariance can be broken by the vacuum that drives the spontaneous symmetry breaking of extra-dimensional extensions of the Standard Model, when delta-like interactions between brane and bulk scalar fields are present. We explicitly build some examples of vacuum configurations, which induce the spontaneous symmetry breaking, and have non trivial profile in the extra coordinate.
Thromboembolic complications remain a central issue in management of patients on mechanical circulatory support. Despite the best practices employed in design and manufacturing of modern ventricular assist devices, complexity and modular nature of these systems often introduces internal steps and crevices in the flow path which can serve as nidus for thrombus formation. Thrombotic potential is influenced by multiple factors including the characteristics of the flow and surface chemistry of the biomaterial. This study explored these elements in the setting of blood flow over a micro-crevice using a multi-constituent numerical model of thrombosis. The simulations reproduced the platelet deposition patterns observed experimentally and elucidated the role of flow, shear rate, and surface chemistry in shaping the deposition. The results offer insights for design and operation of blood-contacting devices.
We show that the metastable, symmetry-breaking ground states of quantum many-body Hamiltonians have vanishing quantum mutual information between macroscopically separated regions, and are thus the most classical ones among all possible quantum ground states. This statement is obvious only when the symmetry-breaking ground states are simple product states, e.g. at the factorization point. On the other hand, symmetry-breaking states are in general entangled along the entire ordered phase, and to show that they actually feature the least macroscopic correlations compared to their symmetric superpositions is highly non trivial. We prove this result in general, by considering the quantum mutual information based on the $2-$Renyi entanglement entropy and using a locality result stemming from quasi-adiabatic continuation. Moreover, in the paradigmatic case of the exactly solvable one-dimensional quantum $XY$ model, we further verify the general result by considering also the quantum mutual information based on the von Neumann entanglement entropy.
We discuss the recent scenario of tachyonic preheating at the end of inflation as a consequence of a tachyonic mass term in the scalar field responsible for spontaneous symmetry breaking. We use 3D lattice simulations to expore this very non-perturbative and non-linear phenomenon, which occurs due to the spinodal instability of the scalar field. Tachyonic preheating is so efficient that symmetry breaking typically completes within a single oscillation of the field distribution as it rolls towards the minimum of its effective potential.
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