In carbon-therapy, the interaction of the incoming beam with human tissues may lead to the production of a large amount of nuclear fragments and secondary light particles. An accurate estimation of the biological dose deposited into the tumor and the surrounding healthy tissues thus requires sophisticated simulation tools based on nuclear reaction models. The validity of such models requires intensive comparisons with as many sets of experimental data as possible. Up to now, a rather limited set of double di erential carbon fragmentation cross sections have been measured in the energy range used in hadrontherapy (up to 400 MeV/A). However, new data have been recently obtained at intermediate energy (95 MeV/A). The aim of this work is to compare the reaction models embedded in the GEANT4 Monte Carlo toolkit with these new data. The strengths and weaknesses of each tested model, i.e. G4BinaryLightIonReaction, G4QMDReaction and INCL++, coupled to two di fferent de-excitation models, i.e. the generalized evaporation model and the Fermi break-up are discussed.
The spin correlation coefficient combinations Axx + Ayy, Axx - Ayy and the analyzing powers Ay(theta) were measured for pp-->pnpi+ at beam energies of 325, 350, 375 and 400 MeV. A polarized internal atomic hydrogen target and a stored, polarized proton beam were used. These polarization observables are sensitive to contributions of higher partial waves. A comparison with recent theoretical calculations is provided.
We present a new global optical potential (GOP) for nucleus-nucleus systems, including neutron-rich and proton-rich isotopes, in the energy range of $50 sim 400$ MeV/u. The GOP is derived from the microscopic folding model with the complex $G$-matrix interaction CEG07 and the global density presented by S{~ a}o Paulo group. The folding model well accounts for realistic complex optical potentials of nucleus-nucleus systems and reproduces the existing elastic scattering data for stable heavy-ion projectiles at incident energies above 50 MeV/u. We then calculate the folding-model potentials (FMPs) for projectiles of even-even isotopes, $^{8-22}$C, $^{12-24}$O, $^{16-38}$Ne, $^{20-40}$Mg, $^{22-48}$Si, $^{26-52}$S, $^{30-62}$Ar, and $^{34-70}$Ca, scattered by stable target nuclei of $^{12}$C, $^{16}$O, $^{28}$Si, $^{40}$Ca $^{58}$Ni, $^{90}$Zr, $^{120}$Sn, and $^{208}$Pb at the incident energy of 50, 60, 70, 80, 100, 120, 140, 160, 180, 200, 250, 300, 350, and 400 MeV/u. The calculated FMP is represented, with a sufficient accuracy, by a linear combination of 10-range Gaussian functions. The expansion coefficients depend on the incident energy, the projectile and target mass numbers and the projectile atomic number, while the range parameters are taken to depend only on the projectile and target mass numbers. The adequate mass region of the present GOP by the global density is inspected in comparison with FMP by realistic density. The full set of the range parameters and the coefficients for all the projectile-target combinations at each incident energy are provided on a permanent open-access website together with a Fortran program for calculating the microscopic-basis GOP (MGOP) for a desired projectile nucleus by the spline interpolation over the incident energy and the target mass number.
During therapeutic treatments using ions such as carbon, nuclear interactions between the incident ions and nuclei present in organic tissues may occur, leading to the attenuation of the incident beam intensity and to the production of secondary light charged particles. As the biological dose deposited in the tumor and the surrounding healthy tissues depends on the beam composition, an accurate knowledge of the fragmentation processes is thus essential. In particular, the nuclear interaction models have to be validated using experimental double differential cross sections which are still very scarce. An experiment was realized in 2011 at GANIL to obtain these cross sections for a 95 MeV/nucleon carbon beam on different thin targets for angles raging from 4 to 43{deg} . In order to complete these data, a new experiment was performed on September 2013 at GANIL to measure the fragmentation cross section at zero degree for a 95 MeV/nucleon carbon beam on thin targets. In this work, the experimental setup will be described, the analysis method detailed and the results presented.
The creation of intense radioactive beams requires intense and energetic primary beams. A task force analysis of this subject recommended an acceleration system capable of 400 MeV/u uranium at 1 particle uA as an appropriate driver for such a facility. The driver system should be capable of accelerating lighter ions at higher intensity such that a constant final beam power (~100kW) is maintained. This document is a more detailed follow on to the previous analysis of such a system incorporating a cyclotron. The proposed driver pre-acceleration system consists of an ion source, radio frequency quadrupole, and linac chain capable of producing a final energy of 30 MeV/u and a charge (Q) to mass (A) of Q/A ~1/3. This acceleration system would be followed by a Separated Sector Cyclotron with a final output energy of 400 MeV/u. This system provides a more cost-effective solution in terms of initial capital investment as well as of operation compared to a fully linac system with the same primary beam output parameters.