The identification of the carrier(s) of diffuse interstellar bands (DIBs) is one of the oldest mysteries in stellar spectroscopy. With the advent of 8-10m-class telescopes substantial progress has been made in measuring the properties of DIBs in the optical and near-infrared wavelength domain, not only in the Galaxy, but also in different environments encountered in Local Group galaxies and beyond. Still, the DIB carriers have remained unidentified. The coming decade will witness the development of extremely large telescopes (GMT, TMT and E-ELT) and their instrumentation. In this overview I will highlight the current instrumentation plan of these future observatories, emphasizing their potential role in solving the enigma of the DIBs.