We obtained VLA 21-cm observations of the galaxy ESO 481-G017 to determine the environment and trigger of remote star formation traced by a HII region found 43 kpc from the galaxy (in projection). ESO 481-G017 is an early type spiral galaxy with a HI mass of 1.1*10^9 Msun and a distance of 55 Mpc. The isolated HII region has a H-alpha luminosity of 10^38.1 erg s^-1 and minimal continuum emission suggesting that new stars have formed where little or no stars previously existed. The difference in velocity between the HI disk of ESO 481-G017 (3840-4000 km s^-1) and the isolated HII region (4701 +/- 80 km s^-1) indicates the origin of the HII region may be stars forming in a tidal feature or newly triggered star formation in a very low luminosity companion galaxy. The VLA observations shed light on the nature of this young object.