This research is aimed at studying the matter of Six Sigma implementation in The Syrian Pharmaceutical Companies as a way to enhance the quality of drug products , and to determine the requirements for successful implementation Six Sigma , and what benefits and obstacles could be appear during the application process . This research has been executed as a case study by implementing Six Sigma Methodology at Orient Pharma. Company to realize the benefits and obstacles of the implementation . In addition to that , the existence of the determined requirements for successful implementation of Six Sigma in the studied company has been measured .And a theoretical study including many of important researches that studied this research's problem has been done , to review the results achieved and benefit of them in executing this study. Then , a simplified conceptual framework about Six Sigma concepts and methods has been formed. After that , the research studied the matter of implementing Six Sigma in Syrian Pharmaceutical Companies , and why they need it , and the fields that’s could benefit from Six Sigma . A group of (16) requirements has been determined as a "must to be" available before stating the application process , these requirements are divided into three main categories : Managerial requirements , Technical requirements , and Human requirements , which create together the suitable environment for successful implementation of Six Sigma.The most important results this research achieved are : it is applicable to use Six Sigma as valuable approach to enhance quality of drug products of the studied company, whereas significant improvements have been achieved through the DMAIC project such as increased quality of the drug product involved in it , decreased variability in the manufacturing process , and enhanced process capability to meet the desired quality requirements of the drug . In addition to that , a significant differences have been detected between the existed requirements in the studied company , and the needed requirements for the successful implementation of Six Sigma . The required role of the company top management , and the resistance of employees are the main obstacles for the successful implementation of Six Sigma in the company.Finally , some recommendations have been suggested to the company such as : the importance of the full existence of the determined requirements for successful implementation of Six Sigma before starting the deployment process , and the viable role of the consultant party that could qualify the employees and provide the needed training about Six Sigma concepts and methods , and to save and sustain the improvements achieved from the DMAIC project executed in the studied company .