An experiment was conducted in fields of Agricultural Research office / Al-Dibuni Research Station in Clay Loam soil, to study the coexistence with irrigation salinity using different water qualities with a recommended mineral fertilizer by the Iraqi Ministry of Agriculture, and evaluate the role of this fertilizer in maintaining the nutritional balance in soil and barley productivity. A Factorial Experiment Design was used According to RCBD design. The results showed that mineral fertilization of 100% fertilizer recommendation was significantly superior in all measured characteristics (nitrogen and phosphorus availability in soil, EC, plant height, leaf area, number of branches, 1000 grain weight, grain yield, biological yield and harvest index) which gave (46.31, 27.29 mg kg-1 , 5.59 dSm-1 , 67.44 cm, 20.41 cm2 plant-1 , 7.66 branch plant-1 , 44.08g, 3.16, 11.19 Mg ha-1 , and 28.24%, respectively) compared with control treatment. The addition of irrigation different types affected on the measured characteristics, as the S1 treatment gave a significant values in each of (nitrogen and phosphorus availability in soil, EC, leaf area, number of branches, 1000 grain weight, grain yield, biological yield and harvest index) which gave (40.27, 23.39 mg kg-1 , 5.10 dSm-1 , 16.97 cm2 plant-1 , 6.91 branch plant-1 , 40.31 g, 3.02, 10.13 Mgha-1 , and 29.98%) compared with S2 treatment. The results showed the double interaction F4S3 treatment had a significant effect in all the measured characteristics(nitrogen and phosphorus availability in soil, leaf area, number of branches, 1000 grain weight, grain yield, biological yield and harvest index) which gave (48.61 and 28.97mg kg-1 and 20. 92 cm2 plant-1 , 8.06 branch plant- 1 , 45.75g, 3.22, 11.47 Mgha -1 , and 28.07%, respectively) compared with F1S2 treatment, noting F4S3 treatment did not significantly of F4S1 treatment.