Cancer is an important global health issue, and colorectal cancer is one of the most common cancers worldwide. It was recently discovered that the systemic inflammatory response plays a supportive role in various types of cancer, including colorectal cancer. The inflammatory response can be reflected by several indexes, including the platelet lymphocyte ratio (PLR).Cancer is an important global health problem, and colorectal cancer is one of the most common cancers. In contrast, the systemic inflammatory response has a warning role in many types of cancer, including colorectal cancer. The inflammatory response can be evaluated with several indicators, including the platelet lymphocyte ratio PLR. Lymphocyte Ratio PLR)) Can't load full results Try again Retrying... Retrying... Our study aimed to evaluate the relation between platelet lymphocyte ratio and to correlate this ratio with the clinicopathological characteristics of non-metastatic colorectal cancer patients. We enrolled 95 non-metastatic colorectal patients at Oncology Depatment at Tishreen University Hospital. Our results revealed that there were statistically significant differences in the higher mean of lymphocyte platelets ratio by the stage of the tumor (p<0.0001), by the size of the tumor (p=0.001), and by the metastases of the lymph nodes (p=0.03), as the mean increases with the tumor stage with the size of the tumor and the formation of metastases in the lymph nodes. While there were no statistically significant differences in the higher mean of lymphocyte platelets by the histological grade of tumor (p = 0.1), as well as by the tumor location in the left and right colon (p= 0.3). These results reflect the correlation of the high percentage of lymphocyte platelets with the histopathological clinical characteristics that indicate a poor prognosis in patients with colorectal cancer