Skin-to-skin contact (SSC) between the mother and her infant immediately post-delivery is an important procedure that must be included in the care given to mother and her infant many health benefits. The mother's desire and reaction towards (SSC) is the decisive factor in the success of this procedure, where personal factors in the mother's life play a role in agreeing to this way of care. Therefore, the present study aims to identifying the mother's initial Reaction to (SSC) with her infant after childbirth, and identifying the factors affecting this and finding a scientific solutions to it. This descriptive study was conducted to investigate the initial reaction of 200 women towards (SSC) immediately after their vaginal delivery were randomly selected from labor section of the obstetric hospital and national children in Lattakia, the data were collected using a developed questionnaire for this purpose. The results showed that nearly three-quarters of mothers agreed to have contact with their children in (SSC) and nearly three-quarters of approvals preferred to be covered. The highest rate of response to approvals for contact with their children immediately after birth was the expression of joy in child and then hugging and kissing him. While the highest response of non-approvals for contact with their children immediately Post-Delivery refused to touch the child because they were suffering of pain, There was also a significant difference between the consent of women to their child's carry and non- carry according to the variables of the cultural level, the economic situation, the number of births and the current state of birth. The study recommended that every mother in the labor room should be investigated for carrying her naked child or swaddled with a blanket immediately after birth, not forcing them to immediately postpartum (SSC), and to conduct continuing education and training courses to provide all midwives and nurses working in labor rooms as well as mothers in their care settings With information and skills on the implementation of SSC between mother and newborn immediately after birth, and further research on nurse and midwife information on the importance of prompt (SSC) immediately Post-Delivery.