In this study, drought in the eastern region of Syria (Hasake, Rakka, DerAzzor, Bokmal & Kameshli) has been investigated using SPI, NDVI indices. We used a set of data containing precipitation data for period from 1975 to 2010 to calculate Standardized Precipitation Index SPI, and MODIS time series images in April for period from 2000 to 2010 to calculate the Normalized Difference Vegetation Index NDVI.