This paper contains the description for the submission of Karlsruhe Institute of Technology (KIT) for the multilingual TEDx translation task in the IWSLT 2021 evaluation campaign. Our main approach is to develop both cascade and end-to-end systems and eventually combine them together to achieve the best possible results for this extremely low-resource setting. The report also confirms certain consistent architectural improvement added to the Transformer architecture, for all tasks: translation, transcription and speech translation.