The evaluation campaign of the International Conference on Spoken Language Translation (IWSLT 2021) featured this year four shared tasks: (i) Simultaneous speech translation, (ii) Offline speech translation, (iii) Multilingual speech translation, (iv) Low-resource speech translation. A total of 22 teams participated in at least one of the tasks. This paper describes each shared task, data and evaluation metrics, and reports results of the received submissions.