Quality Estimation (QE) is an important component of the machine translation workflow as it assesses the quality of the translated output without consulting reference translations. In this paper, we discuss our submission to the WMT 2021 QE Shared Task. We participate in Task 2 sentence-level sub-task that challenge participants to predict the HTER score for sentence-level post-editing effort. Our proposed system is an ensemble of multilingual BERT (mBERT)-based regression models, which are generated by fine-tuning on different input settings. It demonstrates comparable performance with respect to the Pearson's correlation, and beat the baseline system in MAE/ RMSE for several language pairs. In addition, we adapt our system for the zero-shot setting by exploiting target language-relevant language pairs and pseudo-reference translations.