We use soft-collinear effective theory (SCET) to study the factorization properties of deep inelastic scattering in the region of phase space where 1-x = O(Lambda_{QCD/Q}). By applying a regions analysis to loop diagrams in the Breit frame, we show that the appropriate version of SCET includes anti-hard-collinear, collinear, and soft-collinear fields. We find that the effects of the soft-collinear fields spoil perturbative factorization even at leading order in the 1/Q expansion.