We aim to construct quark hadron physics based on QCD. First, using lattice QCD, we study mass spectra of positive-parity and negative-parity baryons in the octet, the decuplet and the singlet representations of the SU(3) flavor. In particular, we consider the lightest negative-parity baryon, the $Lambda$(1405), which can be an exotic hadron as the $N bar K$ molecular state or the flavor-singlet three-quark state. We investigate the negative-parity flavor-singlet three-quark state in lattice QCD using the quenched approximation, where the dynamical quark-anitiquark pair creation is absent and no mixing occurs between the three-quark and the five-quark states. Our lattice QCD analysis suggests that the flavor-singlet three-quark state is so heavy that the $Lambda$(1405) cannot be identified as the three-quark state, which supports the possibility of the molecular-state picture of the $Lambda$(1405). Second, we study thermal properties of the scalar glueball in an anisotropic lattice QCD, and find about 300 MeV mass reduction near the QCD critical temperature from the pole-mass analysis. Finally, we study the three-quark potential, which is responsible to the baryon properties. The detailed lattice QCD analysis for the 3Q potential indicates the Y-type flux-tube formation linking the three quarks.