We present mid-infrared imaging at 11.7 mu m for the quadruple lens systems, PG1115+080 and B1422+231, using the cooled mid-infrared camera and spectrometer (COMICS) attached on the Subaru telescope. These lensed QSOs are characterized by their anomalous optical and radio flux ratios as obtained for (A1, A2) images of PG1115+080 and (A, B, C) images of B1422+231, respectively, i.e., such flux ratios are hardly reproduced by lens models with smooth mass distribution. Our mid-infrared observations for these images have revealed that the mid-infrared flux ratio A2/A1 of PG1115+080 is virtually consistent with smooth lens models (but inconsistent with the optical flux ratio), whereas for B1422+231, the mid-infrared flux ratios among (A, B, C) are in good agreement with the radio flux ratios. We also identify a clear infrared bump in the spectral energy distributions of these QSOs, thereby indicating that the observed mid-infrared fluxes originate from a hot dust torus around a QSO nucleus. Based on the size estimate of the dust torus, we place limits on the mass of a substructure in these lens systems, causing the anomalous optical or radio flux ratios. For PG1115+080, the mass of a substructure inside an Einstein radius, M_E, is < 16 Msun, corresponding to either a star or a low-mass CDM subhalo having the mass of M_{100}^{SIS} < 2.2 * 10^4 Msun inside radius of 100 pc if modeled as a singular isothermal sphere (SIS). For B1422+231, we obtain M_E > 209 Msun, indicating that a CDM subhalo is more likely, having the mass of M_{100}^{SIS} > 7.4 * 10^4 Msun
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