In the presence of Rashba-Dresselhaus coupling, strong spin-orbit interactions in liquid crystal optical cavities result in a distinctive spin-split entangled dispersion. Spin coherence between such modes give rise to an optical persistent-spin-helix. In this letter, we introduce optical gain in such a system, by dispersing a molecular dye in a liquid-crystal microcavity. We demonstrate both lasing in the Rashba-Dresselhaus regime and the emergence of an optical persistent spin helix.