We establish a relation between entanglement in simple quantum mechanical qubit systems and in wormhole physics as considered in the context of the AdS/CFT correspondence. We show that in both cases, states with the same entanglement structure, indistinguishable by any local measurement, nevertheless are characterized by a different Berry phase. This feature is experimentally accessible in coupled qubit systems where states with different Berry phase are related by unitary transformations. In the wormhole case, these transformations are identified with a time evolution of one of the two throats.