We theoretically demonstrate that moire phonons at the lowest-energy bands can become chiral. A general symmetry analysis reveals that they originate from stacking configurations leading to an asymmetric interlayer binding energy that breaks the $C_{2z}$ symmetry on the moire length scale. Within elastic theory, we provide a complete classification of van der Waals heterostructures in respect to hosting moire chiral phonons and discuss their emergence in twisted bilayer MoS$_2$ as an example. The formation of the chiral phonons can be qualitatively understood using an effective model, which emphasizes their origin in the energy difference between stacking domains. Since moire chiral phonons are highly tunable, with excitation energies in only a few meV, and moire scale wavelengths, they might find potential applications in phononic twistronic devices.
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