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Medical imaging datasets are inherently high dimensional with large variability and low sample sizes that limit the effectiveness of deep learning algorithms. Recently, generative adversarial networks (GANs) with the ability to synthesize realist images have shown great potential as an alternative to standard data augmentation techniques. Our work focuses on cross-modality synthesis of fluorodeoxyglucose~(FDG) Positron Emission Tomography~(PET) scans from structural Magnetic Resonance~(MR) images using generative models to facilitate multi-modal diagnosis of Alzheimers disease (AD). Specifically, we propose a novel end-to-end, globally and locally aware image-to-image translation GAN (GLA-GAN) with a multi-path architecture that enforces both global structural integrity and fidelity to local details. We further supplement the standard adversarial loss with voxel-level intensity, multi-scale structural similarity (MS-SSIM) and region-of-interest (ROI) based loss components that reduce reconstruction error, enforce structural consistency at different scales and perceive variation in regional sensitivity to AD respectively. Experimental results demonstrate that our GLA-GAN not only generates synthesized FDG-PET scans with enhanced image quality but also superior clinical utility in improving AD diagnosis compared to state-of-the-art models. Finally, we attempt to interpret some of the internal units of the GAN that are closely related to this specific cross-modality generation task.
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Mild cognitive impairment (MCI) conversion prediction, i.e., identifying MCI patients of high risks converting to Alzheimers disease (AD), is essential for preventing or slowing the progression of AD. Although previous studies have shown that the fusion of multi-modal data can effectively improve the prediction accuracy, their applications are largely restricted by the limited availability or high cost of multi-modal data. Building an effective prediction model using only magnetic resonance imaging (MRI) remains a challenging research topic. In this work, we propose a multi-modal multi-instance distillation scheme, which aims to distill the knowledge learned from multi-modal data to an MRI-based network for MCI conversion prediction. In contrast to existing distillation algorithms, the proposed multi-instance probabilities demonstrate a superior capability of representing the complicated atrophy distributions, and can guide the MRI-based network to better explore the input MRI. To our best knowledge, this is the first study that attempts to improve an MRI-based prediction model by leveraging extra supervision distilled from multi-modal information. Experiments demonstrate the advantage of our framework, suggesting its potentials in the data-limited clinical settings.
In recent years, many papers have reported state-of-the-art performance on Alzheimers Disease classification with MRI scans from the Alzheimers Disease Neuroimaging Initiative (ADNI) dataset using convolutional neural networks. However, we discover that when we split that data into training and testing sets at the subject level, we are not able to obtain similar performance, bringing the validity of many of the previous studies into question. Furthermore, we point out that previous works use different subsets of the ADNI data, making comparison across similar works tricky. In this study, we present the results of three splitting methods, discuss the motivations behind their validity, and report our results using all of the available subjects.
Alzheimers Disease (AD) is one of the most concerned neurodegenerative diseases. In the last decade, studies on AD diagnosis attached great significance to artificial intelligence (AI)-based diagnostic algorithms. Among the diverse modality imaging data, T1-weighted MRI and 18F-FDGPET are widely researched for this task. In this paper, we propose a novel convolutional neural network (CNN) to fuse the multi-modality information including T1-MRI and FDG-PDT images around the hippocampal area for the diagnosis of AD. Different from the traditional machine learning algorithms, this method does not require manually extracted features, and utilizes the stateof-art 3D image-processing CNNs to learn features for the diagnosis and prognosis of AD. To validate the performance of the proposed network, we trained the classifier with paired T1-MRI and FDG-PET images using the ADNI datasets, including 731 Normal (NL) subjects, 647 AD subjects, 441 stable MCI (sMCI) subjects and 326 progressive MCI (pMCI) subjects. We obtained the maximal accuracies of 90.10% for NL/AD task, 87.46% for NL/pMCI task, and 76.90% for sMCI/pMCI task. The proposed framework yields comparative results against state-of-the-art approaches. Moreover, the experimental results have demonstrated that (1) segmentation is not a prerequisite by using CNN, (2) the hippocampal area provides enough information to give a reference to AD diagnosis. Keywords: Alzheimers Disease, Multi-modality, Image Classification, CNN, Deep Learning, Hippocampal
MUSE is a novel slide-free imaging technique for histological examination of tissues that can serve as an alternative to traditional histology. In order to bridge the gap between MUSE and traditional histology, we aim to convert MUSE images to resemble authentic hematoxylin- and eosin-stained (H&E) images. We evaluated four models: a non-machine-learning-based color-mapping unmixing-based tool, CycleGAN, DualGAN, and GANILLA. CycleGAN and GANILLA provided visually compelling results that appropriately transferred H&E style and preserved MUSE content. Based on training an automated critic on real and generated H&E images, we determined that CycleGAN demonstrated the best performance. We have also found that MUSE color inversion may be a necessary step for accurate modality conversion to H&E. We believe that our MUSE-to-H&E model can help improve adoption of novel slide-free methods by bridging a perceptual gap between MUSE imaging and traditional histology.
Our contribution is a unified cross-modality feature disentagling approach for multi-domain image translation and multiple organ segmentation. Using CT as the labeled source domain, our approach learns to segment multi-modal (T1-weighted and T2-weighted) MRI having no labeled data. Our approach uses a variational auto-encoder (VAE) to disentangle the image content from style. The VAE constrains the style feature encoding to match a universal prior (Gaussian) that is assumed to span the styles of all the source and target modalities. The extracted image style is converted into a latent style scaling code, which modulates the generator to produce multi-modality images according to the target domain code from the image content features. Finally, we introduce a joint distribution matching discriminator that combines the translated images with task-relevant segmentation probability maps to further constrain and regularize image-to-image (I2I) translations. We performed extensive comparisons to multiple state-of-the-art I2I translation and segmentation methods. Our approach resulted in the lowest average multi-domain image reconstruction error of 1.34$pm$0.04. Our approach produced an average Dice similarity coefficient (DSC) of 0.85 for T1w and 0.90 for T2w MRI for multi-organ segmentation, which was highly comparable to a fully supervised MRI multi-organ segmentation network (DSC of 0.86 for T1w and 0.90 for T2w MRI).
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