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Register a new userMargin-Aware Intra-Class Novelty Identification for Medical Images
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Xiaoyuan Guo
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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Traditional anomaly detection methods focus on detecting inter-class variations while medical image novelty identification is inherently an intra-class detection problem. For example, a machine learning model trained with normal chest X-ray and common lung abnormalities, is expected to discover and flag idiopathic pulmonary fibrosis which a rare lung disease and unseen by the model during training. The nuances from intra-class variations and lack of relevant training data in medical image analysis pose great challenges for existing anomaly detection methods. To tackle the challenges, we propose a hybrid model - Transformation-based Embedding learning for Novelty Detection (TEND) which without any out-of-distribution training data, performs novelty identification by combining both autoencoder-based and classifier-based method. With a pre-trained autoencoder as image feature extractor, TEND learns to discriminate the feature embeddings of in-distribution data from the transformed counterparts as fake out-of-distribution inputs. To enhance the separation, a distance objective is optimized to enforce a margin between the two classes. Extensive experimental results on both natural image datasets and medical image datasets are presented and our method out-performs state-of-the-art approaches.
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Few-shot object detection has made substantial progressby representing novel class objects using the feature representation learned upon a set of base class objects. However,an implicit contradiction between novel class classification and representation is unfortunately ignored. On the one hand, to achieve accurate novel class classification, the distributions of either two base classes must be far away fromeach other (max-margin). On the other hand, to precisely represent novel classes, the distributions of base classes should be close to each other to reduce the intra-class distance of novel classes (min-margin). In this paper, we propose a class margin equilibrium (CME) approach, with the aim to optimize both feature space partition and novel class reconstruction in a systematic way. CME first converts the few-shot detection problem to the few-shot classification problem by using a fully connected layer to decouple localization features. CME then reserves adequate margin space for novel classes by introducing simple-yet-effective class margin loss during feature learning. Finally, CME pursues margin equilibrium by disturbing the features of novel class instances in an adversarial min-max fashion. Experiments on Pascal VOC and MS-COCO datasets show that CME significantly improves upon two baseline detectors (up to $3sim 5%$ in average), achieving state-of-the-art performance. Code is available at https://github.com/Bohao-Lee/CME .
Though large-scale datasets are essential for training deep learning systems, it is expensive to scale up the collection of medical imaging datasets. Synthesizing the objects of interests, such as lung nodules, in medical images based on the distribu
tion of annotated datasets can be helpful for improving the supervised learning tasks, especially when the datasets are limited by size and class balance. In this paper, we propose the class-aware adversarial synthesis framework to synthesize lung nodules in CT images. The framework is built with a coarse-to-fine patch in-painter (generator) and two class-aware discriminators. By conditioning on the random latent variables and the target nodule labels, the trained networks are able to generate diverse nodules given the same context. By evaluating on the public LIDC-IDRI dataset, we demonstrate an example application of the proposed framework for improving the accuracy of the lung nodule malignancy estimation as a binary classification problem, which is important in the lung screening scenario. We show that combining the real image patches and the synthetic lung nodules in the training set can improve the mean AUC classification score across different network architectures by 2%.
One-class novelty detectors are trained with examples of a particular class and are tasked with identifying whether a query example belongs to the same known class. Most recent advances adopt a deep auto-encoder style architecture to compute novelty scores for detecting novel class data. Deep networks have shown to be vulnerable to adversarial attacks, yet little focus is devoted to studying the adversarial robustness of deep novelty detectors. In this paper, we first show that existing novelty detectors are susceptible to adversarial examples. We further demonstrate that commonly-used defense approaches for classification tasks have limited effectiveness in one-class novelty detection. Hence, we need a defense specifically designed for novelty detection. To this end, we propose a defense strategy that manipulates the latent space of novelty detectors to improve the robustness against adversarial examples. The proposed method, referred to as Principal Latent Space (PLS), learns the incrementally-trained cascade principal components in the latent space to robustify novelty detectors. PLS can purify latent space against adversarial examples and constrain latent space to exclusively model the known class distribution. We conduct extensive experiments on multiple attacks, datasets and novelty detectors, showing that PLS consistently enhances the adversarial robustness of novelty detection models.
Person re-identification (ReID) aims to match people across multiple non-overlapping video cameras deployed at different locations. To address this challenging problem, many metric learning approaches have been proposed, among which triplet loss is one of the state-of-the-arts. In this work, we explore the margin between positive and negative pairs of triplets and prove that large margin is beneficial. In particular, we propose a novel multi-stage training strategy which learns incremental triplet margin and improves triplet loss effectively. Multiple levels of feature maps are exploited to make the learned features more discriminative. Besides, we introduce global hard identity searching method to sample hard identities when generating a training batch. Extensive experiments on Market-1501, CUHK03, and DukeMTMCreID show that our approach yields a performance boost and outperforms most existing state-of-the-art methods.
Contrastive representation learning is an effective unsupervised method to alleviate the demand for expensive annotated data in medical image processing. Recent work mainly based on instance-wise discrimination to learn global features, while neglect local details, which limit their application in processing tiny anatomical structures, tissues and lesions. Therefore, we aim to propose a universal local discrmination framework to learn local discriminative features to effectively initialize medical models, meanwhile, we systematacially investigate its practical medical applications. Specifically, based on the common property of intra-modality structure similarity, i.e. similar structures are shared among the same modality images, a systematic local feature learning framework is proposed. Instead of making instance-wise comparisons based on global embedding, our method makes pixel-wise embedding and focuses on measuring similarity among patches and regions. The finer contrastive rule makes the learnt representation more generalized for segmentation tasks and outperform extensive state-of-the-art methods by wining 11 out of all 12 downstream tasks in color fundus and chest X-ray. Furthermore, based on the property of inter-modality shape similarity, i.e. structures may share similar shape although in different medical modalities, we joint across-modality shape prior into region discrimination to realize unsupervised segmentation. It shows the feaibility of segmenting target only based on shape description from other modalities and inner pattern similarity provided by region discrimination. Finally, we enhance the center-sensitive ability of patch discrimination by introducing center-sensitive averaging to realize one-shot landmark localization, this is an effective application for patch discrimination.
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