Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userActive-set algorithms based statistical inference for shape-restricted generalized additive Cox regression models
112
0
0.0
(
0
)
Added by
Guangning Xu
Publication date
2021
fields
Mathematical Statistics
and research's language is
English
Ask ChatGPT about the research
No Arabic abstract
Recently the shape-restricted inference has gained popularity in statistical and econometric literature in order to relax the linear or quadratic covariate effect in regression analyses. The typical shape-restricted covariate effect includes monotonic increasing, decreasing, convexity or concavity. In this paper, we introduce the shape-restricted inference to the celebrated Cox regression model (SR-Cox), in which the covariate response is modeled as shape-restricted additive functions. The SR-Cox regression approximates the shape-restricted functions using a spline basis expansion with data driven choice of knots. The underlying minimization of negative log-likelihood function is formulated as a convex optimization problem, which is solved with an active-set optimization algorithm. The highlight of this algorithm is that it eliminates the superfluous knots automatically. When covariate effects include combinations of convex or concave terms with unknown forms and linear terms, the most interesting finding is that SR-Cox produces accurate linear covariate effect estimates which are comparable to the maximum partial likelihood estimates if indeed the forms are known. We conclude that concave or convex SR-Cox models could significantly improve nonlinear covariate response recovery and model goodness of fit.
rate research
Read More
We introduce the spike-and-slab group lasso (SSGL) for Bayesian estimation and variable selection in linear regression with grouped variables. We further extend the SSGL to sparse generalized additive models (GAMs), thereby introducing the first nonparametric variant of the spike-and-slab lasso methodology. Our model simultaneously performs group selection and estimation, while our fully Bayes treatment of the mixture proportion allows for model complexity control and automatic self-adaptivity to different levels of sparsity. We develop theory to uniquely characterize the global posterior mode under the SSGL and introduce a highly efficient block coordinate ascent algorithm for maximum a posteriori (MAP) estimation. We further employ de-biasing methods to provide uncertainty quantification of our estimates. Thus, implementation of our model avoids the computational intensiveness of Markov chain Monte Carlo (MCMC) in high dimensions. We derive posterior concentration rates for both grouped linear regression and sparse GAMs when the number of covariates grows at nearly exponential rate with sample size. Finally, we illustrate our methodology through extensive simulations and data analysis.
Point processes in time have a wide range of applications that include the claims arrival process in insurance or the analysis of queues in operations research. Due to advances in technology, such samples of point processes are increasingly encountered. A key object of interest is the local intensity function. It has a straightforward interpretation that allows to understand and explore point process data. We consider functional approaches for point processes, where one has a sample of repeated realizations of the point process. This situation is inherently connected with Cox processes, where the intensity functions of the replications are modeled as random functions. Here we study a situation where one records covariates for each replication of the process, such as the daily temperature for bike rentals. For modeling point processes as responses with vector covariates as predictors we propose a novel regression approach for the intensity function that is intrinsically nonparametric. While the intensity function of a point process that is only observed once on a fixed domain cannot be identified, we show how covariates and repeated observations of the process can be utilized to make consistent estimation possible, and we also derive asymptotic rates of convergence without invoking parametric assumptions.
Field observations form the basis of many scientific studies, especially in ecological and social sciences. Despite efforts to conduct such surveys in a standardized way, observations can be prone to systematic measurement errors. The removal of systematic variability introduced by the observation process, if possible, can greatly increase the value of this data. Existing non-parametric techniques for correcting such errors assume linear additive noise models. This leads to biased estimates when applied to generalized linear models (GLM). We present an approach based on residual functions to address this limitation. We then demonstrate its effectiveness on synthetic data and show it reduces systematic detection variability in moth surveys.
With the availability of high dimensional genetic biomarkers, it is of interest to identify heterogeneous effects of these predictors on patients survival, along with proper statistical inference. Censored quantile regression has emerged as a powerful tool for detecting heterogeneous effects of covariates on survival outcomes. To our knowledge, there is little work available to draw inference on the effects of high dimensional predictors for censored quantile regression. This paper proposes a novel procedure to draw inference on all predictors within the framework of global censored quantile regression, which investigates covariate-response associations over an interval of quantile levels, instead of a few discrete values. The proposed estimator combines a sequence of low dimensional model estimates that are based on multi-sample splittings and variable selection. We show that, under some regularity conditions, the estimator is consistent and asymptotically follows a Gaussian process indexed by the quantile level. Simulation studies indicate that our procedure can properly quantify the uncertainty of the estimates in high dimensional settings. We apply our method to analyze the heterogeneous effects of SNPs residing in lung cancer pathways on patients survival, using the Boston Lung Cancer Survival Cohort, a cancer epidemiology study on the molecular mechanism of lung cancer.
This paper considers the problem of variable selection in regression models in the case of functional variables that may be mixed with other type of variables (scalar, multivariate, directional, etc.). Our proposal begins with a simple null model and sequentially selects a new variable to be incorporated into the model based on the use of distance correlation proposed by cite{Szekely2007}. For the sake of simplicity, this paper only uses additive models. However, the proposed algorithm may assess the type of contribution (linear, non linear, ...) of each variable. The algorithm has shown quite promising results when applied to simulations and real data sets.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
