It is well known that domain-decomposition-based multiscale mixed methods rely on interface spaces, defined on the skeleton of the decomposition, to connect the solution among the non-overlapping subdomains. Usual spaces, such as polynomial-based ones, cannot properly represent high-contrast channelized features such as fractures (high permeability) and barriers (low permeability) for flows in heterogeneous porous media. We propose here new interface spaces, which are based on physics, to deal with permeability fields in the simultaneous presence of fractures and barriers, accommodated respectively, by the pressure and flux spaces. Existing multiscale methods based on mixed formulations can take advantage of the proposed interface spaces, however, in order to present and test our results, we use the newly developed Multiscale Robin Coupled Method (MRCM) [Guiraldello, et al., J. Comput. Phys., 355 (2018) pp. 1-21], which generalizes most well-known multiscale mixed methods, and allows for the independent choice of the pressure and flux interface spaces. An adaptive version of the MRCM [Rocha, et al., J. Comput. Phys., 409 (2020), 109316] is considered that automatically selects the physics-based pressure space for fractured structures and the physics-based flux space for regions with barriers, resulting in a procedure with unprecedented accuracy. The features of the proposed approach are investigated through several numerical simulations of single-phase and two-phase flows, in different heterogeneous porous media. The adaptive MRCM combined with the interface spaces based on physics provides promising results for challenging problems with the simultaneous presence of fractures and barriers.