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Register a new userCross Chest Graph for Disease Diagnosis with Structural Relational Reasoning
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Added by
Gangming Zhao
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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Locating lesions is important in the computer-aided diagnosis of X-ray images. However, box-level annotation is time-consuming and laborious. How to locate lesions accurately with few, or even without careful annotations is an urgent problem. Although several works have approached this problem with weakly-supervised methods, the performance needs to be improved. One obstacle is that general weakly-supervised methods have failed to consider the characteristics of X-ray images, such as the highly-structural attribute. We therefore propose the Cross-chest Graph (CCG), which improves the performance of automatic lesion detection by imitating doctors training and decision-making process. CCG models the intra-image relationship between different anatomical areas by leveraging the structural information to simulate the doctors habit of observing different areas. Meanwhile, the relationship between any pair of images is modeled by a knowledge-reasoning module to simulate the doctors habit of comparing multiple images. We integrate intra-image and inter-image information into a unified end-to-end framework. Experimental results on the NIH Chest-14 database (112,120 frontal-view X-ray images with 14 diseases) demonstrate that the proposed method achieves state-of-the-art performance in weakly-supervised localization of lesions by absorbing professional knowledge in the medical field.
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Image representation is a fundamental task in computer vision. However, most of the existing approaches for image representation ignore the relations between images and consider each input image independently. Intuitively, relations between images can help to understand the images and maintain model consistency over related images. In this paper, we consider modeling the image-level relations to generate more informative image representations, and propose ImageGCN, an end-to-end graph convolutional network framework for multi-relational image modeling. We also apply ImageGCN to chest X-ray (CXR) images where rich relational information is available for disease identification. Unlike previous image representation models, ImageGCN learns the representation of an image using both its original pixel features and the features of related images. Besides learning informative representations for images, ImageGCN can also be used for object detection in a weakly supervised manner. The Experimental results on ChestX-ray14 dataset demonstrate that ImageGCN can outperform respective baselines in both disease identification and localization tasks and can achieve comparable and often better results than the state-of-the-art methods.
Thoracic diseases are very serious health problems that plague a large number of people. Chest X-ray is currently one of the most popular methods to diagnose thoracic diseases, playing an important role in the healthcare workflow. However, reading the chest X-ray images and giving an accurate diagnosis remain challenging tasks for expert radiologists. With the success of deep learning in computer vision, a growing number of deep neural network architectures were applied to chest X-ray image classification. However, most of the previous deep neural network classifiers were based on deterministic architectures which are usually very noise-sensitive and are likely to aggravate the overfitting issue. In this paper, to make a deep architecture more robust to noise and to reduce overfitting, we propose using deep generative classifiers to automatically diagnose thorax diseases from the chest X-ray images. Unlike the traditional deterministic classifier, a deep generative classifier has a distribution middle layer in the deep neural network. A sampling layer then draws a random sample from the distribution layer and input it to the following layer for classification. The classifier is generative because the class label is generated from samples of a related distribution. Through training the model with a certain amount of randomness, the deep generative classifiers are expected to be robust to noise and can reduce overfitting and then achieve good performances. We implemented our deep generative classifiers based on a number of well-known deterministic neural network architectures, and tested our models on the chest X-ray14 dataset. The results demonstrated the superiority of deep generative classifiers compared with the corresponding deep deterministic classifiers.
Solving grounded language tasks often requires reasoning about relationships between objects in the context of a given task. For example, to answer the question What color is the mug on the plate? we must check the color of the specific mug that satisfies the on relationship with respect to the plate. Recent work has proposed various methods capable of complex relational reasoning. However, most of their power is in the inference structure, while the scene is represented with simple local appearance features. In this paper, we take an alternate approach and build contextualized representations for objects in a visual scene to support relational reasoning. We propose a general framework of Language-Conditioned Graph Networks (LCGN), where each node represents an object, and is described by a context-aware representation from related objects through iterative message passing conditioned on the textual input. E.g., conditioning on the on relationship to the plate, the object mug gathers messages from the object plate to update its representation to mug on the plate, which can be easily consumed by a simple classifier for answer prediction. We experimentally show that our LCGN approach effectively supports relational reasoning and improves performance across several tasks and datasets. Our code is available at http://ronghanghu.com/lcgn.
Vision-and-language(V&L) models take image and text as input and learn to capture the associations between them. Prior studies show that pre-trained V&L models can significantly improve the model performance for downstream tasks such as Visual Question Answering (VQA). However, V&L models are less effective when applied in the medical domain (e.g., on X-ray images and clinical notes) due to the domain gap. In this paper, we investigate the challenges of applying pre-trained V&L models in medical applications. In particular, we identify that the visual representation in general V&L models is not suitable for processing medical data. To overcome this limitation, we propose BERTHop, a transformer-based model based on PixelHop++ and VisualBERT, for better capturing the associations between the two modalities. Experiments on the OpenI dataset, a commonly used thoracic disease diagnosis benchmark, show that BERTHop achieves an average Area Under the Curve (AUC) of 98.12% which is 1.62% higher than state-of-the-art (SOTA) while it is trained on a 9 times smaller dataset.
With the aim of matching a pair of instances from two different modalities, cross modality mapping has attracted growing attention in the computer vision community. Existing methods usually formulate the mapping function as the similarity measure between the pair of instance features, which are embedded to a common space. However, we observe that the relationships among the instances within a single modality (intra relations) and those between the pair of heterogeneous instances (inter relations) are insufficiently explored in previous approaches. Motivated by this, we redefine the mapping function with relational reasoning via graph modeling, and further propose a GCN-based Relational Reasoning Network (RR-Net) in which inter and intra relations are efficiently computed to universally resolve the cross modality mapping problem. Concretely, we first construct two kinds of graph, i.e., Intra Graph and Inter Graph, to respectively model intra relations and inter relations. Then RR-Net updates all the node features and edge features in an iterative manner for learning intra and inter relations simultaneously. Last, RR-Net outputs the probabilities over the edges which link a pair of heterogeneous instances to estimate the mapping results. Extensive experiments on three example tasks, i.e., image classification, social recommendation and sound recognition, clearly demonstrate the superiority and universality of our proposed model.
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