Local three- and four-point correlators yield important insight into strongly correlated systems and have many applications. However, the non-perturbative, accurate computation of multipoint correlators is challenging, particularly in the real-frequency domain for systems at low temperatures. In an accompanying paper, we introduce generalized spectral representations for multipoint correlators. Here, we develop a numerical renormalization group (NRG) approach, capable of efficiently evaluating these spectral representations, to compute local three- and four-point correlators of quantum impurity models. The key objects in our scheme are partial spectral functions, encoding the systems dynamical information. Their computation via NRG allows us to simultaneously resolve various multiparticle excitations down to the lowest energies. By subsequently convolving the partial spectral functions with appropriate kernels, we obtain multipoint correlators in the imaginary-frequency Matsubara, the real-frequency zero-temperature, and the real-frequency Keldysh formalisms. We present exemplary results for the connected four-point correlators of the Anderson impurity model, and for resonant inelastic x-ray scattering (RIXS) spectra of related impurity models. Our method can treat temperatures and frequencies -- imaginary or real -- of all magnitudes, from large to arbitrarily small ones.