Large Liquid Argon Time Projection Chambers (LArTPCs) are being increasingly adopted in neutrino oscillation experiments because of their superb imaging capabilities through the combination of both tracking and calorimetry in a fully active volume. Active LArTPC neutrino detectors at or near the Earths surface, such as the MicroBooNE experiment, present a unique analysis challenge because of the large flux of cosmic-ray muons and the slow drift of ionization electrons. We present a novel Wire-Cell-based high-performance generic neutrino-detection technique implemented in MicroBooNE. The cosmic-ray background is reduced by a factor of 1.4$times10^{5}$ resulting in a 9.7% cosmic contamination in the selected neutrino candidate events, for visible energies greater than 200~MeV, while the neutrino signal efficiency is retained at 88.4% for $ u_{mu}$ charged-current interactions in the fiducial volume in the same energy region. This significantly improved performance compared to existing reconstruction algorithms, marks a major milestone toward reaching the scientific goals of LArTPC neutrino oscillation experiments operating near the Earths surface.
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