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Register a new userCOVID-19 what have we learned? The rise of social machines and connected devices in pandemic management following the concepts of predictive, preventive and personalised medicine
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Petar Radanliev
Publication date
2020
fields
Informatics Engineering
and research's language is
English
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A comprehensive bibliographic review with R statistical methods of the COVID pandemic in PubMed literature and Web of Science Core Collection, supported with Google Scholar search. In addition, a case study review of emerging new approaches in different regions, using medical literature, academic literature, news articles and other reliable data sources. Public responses of mistrust about privacy data misuse differ across countries, depending on the chosen public communication strategy.
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What makes cyber risks arising from connected systems challenging during the management of a pandemic? Assuming that a variety of cyber-physical systems are already operational-collecting, analyzing, and acting on data autonomously-what risks might arise in their application to pandemic management? We already have these systems operational, collecting, and analyzing data autonomously, so how would a pandemic monitoring app be different or riskier? In this review article, we discuss the digitalization of COVID-19 pandemic management and cyber risk from connected systems.
Anonymous peer review is used by the great majority of computer science conferences. OpenReview is such a platform that aims to promote openness in peer review process. The paper, (meta) reviews, rebuttals, and final decisions are all released to public. We collect 5,527 submissions and their 16,853 reviews from the OpenReview platform. We also collect these submissions citation data from Google Scholar and their non-peer-review
In this study, we investigate the scientific research response from the early stages of the pandemic, and we review key findings on how the early warning systems developed in previous epidemics responded to contain the virus. The data records are analysed with commutable statistical methods, including R Studio, Bibliometrix package, and the Web of Science data mining tool. We identified few different clusters, containing references to exercise, inflammation, smoking, obesity and many additional factors. From the analysis on Covid-19 and vaccine, we discovered that although the USA is leading in volume of scientific research on Covid 19 vaccine, the leading 3 research institutions (Fudan, Melbourne, Oxford) are not based in the USA. Hence, it is difficult to predict which country would be first to produce a Covid 19 vaccine.
I revisit two theories of cell differentiation in multicellular organisms published a half-century ago, Stuart Kauffmans global gene regulatory dynamics (GGRD) model and Roy Brittens and Eric Davidsons modular gene regulatory network (MGRN) model, in light of newer knowledge of mechanisms of gene regulation in the metazoans (animals). The two models continue to inform hypotheses and computational studies of differentiation of lineage-adjacent cell types. However, their shared notion (based on bacterial regulatory systems) of gene switches and networks built from them, have constrained progress in understanding the dynamics and evolution of differentiation. Recent work has described unique write-read-rewrite chromatin-based expression encoding in eukaryotes, as well metazoan-specific processes of gene activation and silencing in condensed-phase, enhancer-recruiting regulatory hubs, employing disordered proteins, including transcription factors, with context-dependent identities. These findings suggest an evolutionary scenario in which the origination of differentiation in animals, rather than depending exclusively on adaptive natural selection, emerged as a consequence of a type of multicellularity in which the novel metazoan gene regulatory apparatus was readily mobilized to amplify and exaggerate inherent cell functions of unicellular ancestors. The plausibility of this hypothesis is illustrated by the evolution of the developmental role of Grainyhead-like in the formation of epithelium.
Most work to date on mitigating the COVID-19 pandemic is focused urgently on biomedicine and epidemiology. Yet, pandemic-related policy decisions cannot be made on health information alone. Decisions need to consider the broader impacts on people and their needs. Quantifying human needs across the population is challenging as it requires high geo-temporal granularity, high coverage across the population, and appropriate adjustment for seasonal and other external effects. Here, we propose a computational methodology, building on Maslows hierarchy of needs, that can capture a holistic view of relative changes in needs following the pandemic through a difference-in-differences approach that corrects for seasonality and volume variations. We apply this approach to characterize changes in human needs across physiological, socioeconomic, and psychological realms in the US, based on more than 35 billion search interactions spanning over 36,000 ZIP codes over a period of 14 months. The analyses reveal that the expression of basic human needs has increased exponentially while higher-level aspirations declined during the pandemic in comparison to the pre-pandemic period. In exploring the timing and variations in statewide policies, we find that the durations of shelter-in-place mandates have influenced social and emotional needs significantly. We demonstrate that potential barriers to addressing critical needs, such as support for unemployment and domestic violence, can be identified through web search interactions. Our approach and results suggest that population-scale monitoring of shifts in human needs can inform policies and recovery efforts for current and anticipated needs.
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