Isotopy and equivalence of knots in 3-manifolds

We show that in a prime, closed, oriented 3-manifold M, equivalent knots are isotopic if and only if the orientation preserving mapping class group is trivial. In the case of irreducible, closed, oriented $3$-manifolds we show the more general fact that every orientation preserving homeomorphism which preserves free homotopy classes of loops is isotopic to the identity. In the case of $S^1times S^2$, we give infinitely many examples of knots whose isotopy classes are changed by the Gluck twist.