We perform a systematic search for high-redshift ($z >$ 1.5) extreme variability quasars (EVQs) using repeat spectra from the Sixteenth Data Release of Sloan Digital Sky Survey, which provides a baseline spanning up to $sim$18 yrs in the observed frame. We compile a sample of 348 EVQs with a maximum continuum variability at rest frame 1450 Angstrom of more than 100% (i.e., $delta$V $equiv$ (Max$-$Min)/Mean $>$1). The EVQs show a range of emission line variability, including 23 where at least one line in our redshift range disappears below detectability, which can then be seen as analogous to low-redshift changing-look quasars (CLQs). Importantly, spurious CLQs caused by SDSS problematic spectral flux calibration, e.g., fiber drop issue, have been rejected. The similar properties (e.g., continuum/line, difference-composite spectra and Eddington ratio) of normal EVQs and CLQs, implies that they are basically the same physical population with analogous intrinsic variability mechanisms, as a tail of a continuous distribution of normal quasar properties. In addition, we find no reliable evidence ($lesssim$ 1$sigma$) to support that the CLQs are a subset of EVQs with less efficient accretion. Finally, we also confirm the anti-breathing of C IV (i.e., line width increases as luminosity increases) in EVQs, and find that in addition to $sim$ 0.4 dex systematic uncertainty in single-epoch C IV virial black hole mass estimates, an extra scatter of $sim$ 0.3 dex will be introduced by extreme variability.
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