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Register a new userControl of tumour growth distributions through kinetic methods
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The mathematical modeling of tumor growth has a long history, and has been mathematically formulated in several different ways. Here we tackle the problem in the case of a continuous distribution using mathematical tools from statistical physics. To this extent, we introduce a novel kinetic model of growth which highlights the role of microscopic transitions in determining a variety of equilibrium distributions. At variance with other approaches, the mesoscopic description in terms of elementary interactions allows to design precise microscopic feedback control therapies, able to influence the natural tumor growth and to mitigate the risk factors involved in big sized tumors. We further show that under a suitable scaling both the free and controlled growth models correspond to Fokker--Planck type equations for the growth distribution with variable coefficients of diffusion and drift, whose steady solutions in the free case are given by a class of generalized Gamma densities which can be characterized by fat tails. In this scaling the feedback control produces an explicit modification of the drift operator, which is shown to strongly modify the emerging distribution for the tumor size. In particular, the size distributions in presence of therapies manifest slim tails in all growth models, which corresponds to a marked mitigation of the risk factors. Numerical results confirming the theoretical analysis are also presented.
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Starting from a master equation, we derive the evolution equation for the size distribution of elements in an evolving system, where each element can grow, divide into two, and produce new elements. We then probe general solutions of the evolution quation, to obtain such skew distributions as power-law, log-normal, and Weibull distributions, depending on the growth or division and production. Specifically, repeated production of elements of uniform size leads to power-law distributions, whereas production of elements with the size distributed according to the current distribution as well as no production of new elements results in log-normal distributions. Finally, division into two, or binary fission, bears Weibull distributions. Numerical simulations are also carried out, confirming the validity of the obtained solutions.
We look into the minimisation of the connection time between non-equilibrium steady states. As a prototypical example of an intrinsically non-equilibrium system, a driven granular gas is considered. For time-independent driving, its natural time scale for relaxation is characterised from an empirical -- the relaxation function -- and a theoretical -- the recently derived classical speed limits -- point of view. Using control theory, we find that bang-bang protocols -- comprising two steps, heating with the largest possible value of the driving and cooling with zero driving -- minimise the connecting time. The bang-bang time is shorter than both the empirical relaxation time and the classical speed limit: in this sense, the natural time scale for relaxation is beaten. Information theory quantities stemming from the Fisher information are also analysed over these optimal protocols. The implementation of the bang-bang processes in numerical simulations of the dynamics of the granular gas show an excellent agreement with the theoretical predictions. Moreover, general implications of our results are discussed for a wide class of driven non-equilibrium systems. Specifically, we show that analogous bang-bang protocols, with a number of bangs equal to the number of relevant physical variables, give the minimum connecting time under quite general conditions.
To study epitaxial thin-film growth, a new model is introduced and extensive kinetic Monte Carlo simulations performed for a wide range of fluxes and temperatures. Varying the deposition conditions, a rich growth diagram is found. The model also reproduces several known regimes and in the limit of low particle mobility a new regime is defined. Finally, a relation is postulated between the temperatures of the kinetic and thermal roughening transitions.
The spread of COVID-19 has been thwarted in most countries through non-pharmaceutical interventions. In particular, the most effective measures in this direction have been the stay-at-home and closure strategies of businesses and schools. However, population-wide lockdowns are far from being optimal carrying heavy economic consequences. Therefore, there is nowadays a strong interest in designing more efficient restrictions. In this work, starting from a recent kinetic-type model which takes into account the heterogeneity described by the social contact of individuals, we analyze the effects of introducing an optimal control strategy into the system, to limit selectively the mean number of contacts and reduce consequently the number of infected cases. Thanks to a data-driven approach, we show that this new mathematical model permits to assess the effects of the social limitations. Finally, using the model introduced here and starting from the available data, we show the effectivity of the proposed selective measures to dampen the epidemic trends.
We study the derivation of generic high order macroscopic traffic models from a follow-the-leader particle description via a kinetic approach. First, we recover a third order traffic model as the hydrodynamic limit of an Enskog-type kinetic equation. Next, we introduce in the vehicle interactions a binary control modelling the automatic feedback provided by driver-assist vehicles and we upscale such a new particle description by means of another Enskog-based hydrodynamic limit. The resulting macroscopic model is now a Generic Second Order Model (GSOM), which contains in turn a control term inherited from the microscopic interactions. We show that such a control may be chosen so as to optimise global traffic trends, such as the vehicle flux or the road congestion, constrained by the GSOM dynamics. By means of numerical simulations, we investigate the effect of this control hierarchy in some specific case studies, which exemplify the multiscale path from the vehicle-wise implementation of a driver-assist control to its optimal hydrodynamic design.
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