We report on photometry and high resolution spectroscopy of the chemically peculiar Jupiter-family Comet (hereafter JFC) 21P/Giacobini-Zinner. Comet 21P is a well known member of the carbon-chain depleted family but displays also a depletion of amines. We monitored continuously the comet over more than seven months with the two TRAPPIST telescopes (TN and TS), covering a large heliocentric distance range from 1.60 au inbound to 2.10 au outbound with a perihelion at 1.01 au on September 10, 2018. We computed and followed the evolution of the dust (represented by Af$rho$) and gas production rates of the daughter species OH, NH, CN, C$_3$, and C$_2$ and their relative abundances to OH and to CN over the comet orbit. We compared them to those measured in the previous apparitions. The activity of the comet and its water production rate reached a maximum of (3.72$pm$0.07)$times$10$^{28}$ molec/s on August 17, 2018 (r$_h$=1.07 au), 24 days before perihelion. The peak value of A(0)f$rho$ was reached on the same date (1646$pm$13) cm in the red filter. The abundance ratios of the various species are remarkably constant over a large range of heliocentric distances, before and after perihelion, showing a high level of homogeneity of the ices in the surface of the nucleus. The behaviour and level of the activity of the comet is also remarkably similar over the last five orbits. About the coma dust colour, 21P shows reflectively gradients similar to JFCs. We obtained a high resolution spectrum of 21P with UVES at ESO VLT one week after perihelion. Using the CN B-X (0,0) violet band, we measured $^{12}$C/$^{13}$C and $^{14}$N/$^{15}$N isotopic ratios of 100$pm$10 and 145$pm$10, respectively, both in very good agreement with what is usually found in comets.
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