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Register a new userRobust Automatic Whole Brain Extraction on Magnetic Resonance Imaging of Brain Tumor Patients using Dense-Vnet
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Sara Ranjbar
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Whole brain extraction, also known as skull stripping, is a process in neuroimaging in which non-brain tissue such as skull, eyeballs, skin, etc. are removed from neuroimages. Skull striping is a preliminary step in presurgical planning, cortical reconstruction, and automatic tumor segmentation. Despite a plethora of skull stripping approaches in the literature, few are sufficiently accurate for processing pathology-presenting MRIs, especially MRIs with brain tumors. In this work we propose a deep learning approach for skull striping common MRI sequences in oncology such as T1-weighted with gadolinium contrast (T1Gd) and T2-weighted fluid attenuated inversion recovery (FLAIR) in patients with brain tumors. We automatically created gray matter, white matter, and CSF probability masks using SPM12 software and merged the masks into one for a final whole-brain mask for model training. Dice agreement, sensitivity, and specificity of the model (referred herein as DeepBrain) was tested against manual brain masks. To assess data efficiency, we retrained our models using progressively fewer training data examples and calculated average dice scores on the test set for the models trained in each round. Further, we tested our model against MRI of healthy brains from the LBP40A dataset. Overall, DeepBrain yielded an average dice score of 94.5%, sensitivity of 96.4%, and specificity of 98.5% on brain tumor data. For healthy brains, model performance improved to a dice score of 96.2%, sensitivity of 96.6% and specificity of 99.2%. The data efficiency experiment showed that, for this specific task, comparable levels of accuracy could have been achieved with as few as 50 training samples. In conclusion, this study demonstrated that a deep learning model trained on minimally processed automatically-generated labels can generate more accurate brain masks on MRI of brain tumor patients within seconds.
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Brain magnetic resonance (MR) segmentation for hydrocephalus patients is considered as a challenging work. Encoding the variation of the brain anatomical structures from different individuals cannot be easily achieved. The task becomes even more difficult especially when the image data from hydrocephalus patients are considered, which often have large deformations and differ significantly from the normal subjects. Here, we propose a novel strategy with hard and soft attention modules to solve the segmentation problems for hydrocephalus MR images. Our main contributions are three-fold: 1) the hard-attention module generates coarse segmentation map using multi-atlas-based method and the VoxelMorph tool, which guides subsequent segmentation process and improves its robustness; 2) the soft-attention module incorporates position attention to capture precise context information, which further improves the segmentation accuracy; 3) we validate our method by segmenting insula, thalamus and many other regions-of-interests (ROIs) that are critical to quantify brain MR images of hydrocephalus patients in real clinical scenario. The proposed method achieves much improved robustness and accuracy when segmenting all 17 consciousness-related ROIs with high variations for different subjects. To the best of our knowledge, this is the first work to employ deep learning for solving the brain segmentation problems of hydrocephalus patients.
Background: Glioma is the most common brain malignant tumor, with a high morbidity rate and a mortality rate of more than three percent, which seriously endangers human health. The main method of acquiring brain tumors in the clinic is MRI. Segmentation of brain tumor regions from multi-modal MRI scan images is helpful for treatment inspection, post-diagnosis monitoring, and effect evaluation of patients. However, the common operation in clinical brain tumor segmentation is still manual segmentation, lead to its time-consuming and large performance difference between different operators, a consistent and accurate automatic segmentation method is urgently needed. Methods: To meet the above challenges, we propose an automatic brain tumor MRI data segmentation framework which is called AGSE-VNet. In our study, the Squeeze and Excite (SE) module is added to each encoder, the Attention Guide Filter (AG) module is added to each decoder, using the channel relationship to automatically enhance the useful information in the channel to suppress the useless information, and use the attention mechanism to guide the edge information and remove the influence of irrelevant information such as noise. Results: We used the BraTS2020 challenge online verification tool to evaluate our approach. The focus of verification is that the Dice scores of the whole tumor (WT), tumor core (TC) and enhanced tumor (ET) are 0.68, 0.85 and 0.70, respectively. Conclusion: Although MRI images have different intensities, AGSE-VNet is not affected by the size of the tumor, and can more accurately extract the features of the three regions, it has achieved impressive results and made outstanding contributions to the clinical diagnosis and treatment of brain tumor patients.
Cancer is a complex disease that provides various types of information depending on the scale of observation. While most tumor diagnostics are performed by observing histopathological slides, radiology images should yield additional knowledge towards the efficacy of cancer diagnostics. This work investigates a deep learning method combining whole slide images and magnetic resonance images to classify tumors. In particular, our solution comprises a powerful, generic and modular architecture for whole slide image classification. Experiments are prospectively conducted on the 2020 Computational Precision Medicine challenge, in a 3-classes unbalanced classification task. We report cross-validation (resp. validation) balanced-accuracy, kappa and f1 of 0.913, 0.897 and 0.951 (resp. 0.91, 0.90 and 0.94). For research purposes, including reproducibility and direct performance comparisons, our finale submitted models are usable off-the-shelf in a Docker image available at https://hub.docker.com/repository/docker/marvinler/cpm_2020_marvinler.
According to the World Health Organization, cancer is the second leading cause of death worldwide, responsible for over 9.5 million deaths in 2018 alone. Brain tumors count for one out of every four cancer deaths. Accurate and timely diagnosis of brain tumors will lead to more effective treatments. To date, several image classification approaches have been proposed to aid diagnosis and treatment. We propose an encoder layer that uses post-max-pooling features for residual learning. Our approach shows promising results by improving the tumor classification accuracy in MR images using a limited medical image dataset. Experimental evaluations of this model on a dataset consisting of 3064 MR images show 95-98% accuracy, which is better than previous studies on this database.
We present a joint graph convolution-image convolution neural network as our submission to the Brain Tumor Segmentation (BraTS) 2021 challenge. We model each brain as a graph composed of distinct image regions, which is initially segmented by a graph neural network (GNN). Subsequently, the tumorous volume identified by the GNN is further refined by a simple (voxel) convolutional neural network (CNN), which produces the final segmentation. This approach captures both global brain feature interactions via the graphical representation and local image details through the use of convolutional filters. We find that the GNN component by itself can effectively identify and segment the brain tumors. The addition of the CNN further improves the median performance of the model by 2 percent across all metrics evaluated. On the validation set, our joint GNN-CNN model achieves mean Dice scores of 0.89, 0.81, 0.73 and mean Hausdorff distances (95th percentile) of 6.8, 12.6, 28.2mm on the whole tumor, core tumor, and enhancing tumor, respectively.
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