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COVID-19 Chest CT Image Segmentation -- A Deep Convolutional Neural Network Solution

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 Added by Qingsen Yan
 Publication date 2020
and research's language is English




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A novel coronavirus disease 2019 (COVID-19) was detected and has spread rapidly across various countries around the world since the end of the year 2019, Computed Tomography (CT) images have been used as a crucial alternative to the time-consuming RT-PCR test. However, pure manual segmentation of CT images faces a serious challenge with the increase of suspected cases, resulting in urgent requirements for accurate and automatic segmentation of COVID-19 infections. Unfortunately, since the imaging characteristics of the COVID-19 infection are diverse and similar to the backgrounds, existing medical image segmentation methods cannot achieve satisfactory performance. In this work, we try to establish a new deep convolutional neural network tailored for segmenting the chest CT images with COVID-19 infections. We firstly maintain a large and new chest CT image dataset consisting of 165,667 annotated chest CT images from 861 patients with confirmed COVID-19. Inspired by the observation that the boundary of the infected lung can be enhanced by adjusting the global intensity, in the proposed deep CNN, we introduce a feature variation block which adaptively adjusts the global properties of the features for segmenting COVID-19 infection. The proposed FV block can enhance the capability of feature representation effectively and adaptively for diverse cases. We fuse features at different scales by proposing Progressive Atrous Spatial Pyramid Pooling to handle the sophisticated infection areas with diverse appearance and shapes. We conducted experiments on the data collected in China and Germany and show that the proposed deep CNN can produce impressive performance effectively.



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The novel corona-virus disease (COVID-19) pandemic has caused a major outbreak in more than 200 countries around the world, leading to a severe impact on the health and life of many people globally. As of Aug 25th of 2020, more than 20 million people are infected, and more than 800,000 death are reported. Computed Tomography (CT) images can be used as a as an alternative to the time-consuming reverse transcription polymerase chain reaction (RT-PCR) test, to detect COVID-19. In this work we developed a deep learning framework to predict COVID-19 from CT images. We propose to use an attentional convolution network, which can focus on the infected areas of chest, enabling it to perform a more accurate prediction. We trained our model on a dataset of more than 2000 CT images, and report its performance in terms of various popular metrics, such as sensitivity, specificity, area under the curve, and also precision-recall curve, and achieve very promising results. We also provide a visualization of the attention maps of the model for several test images, and show that our model is attending to the infected regions as intended. In addition to developing a machine learning modeling framework, we also provide the manual annotation of the potentionally infected regions of chest, with the help of a board-certified radiologist, and make that publicly available for other researchers.
The health and socioeconomic difficulties caused by the COVID-19 pandemic continues to cause enormous tensions around the world. In particular, this extraordinary surge in the number of cases has put considerable strain on health care systems around the world. A critical step in the treatment and management of COVID-19 positive patients is severity assessment, which is challenging even for expert radiologists given the subtleties at different stages of lung disease severity. Motivated by this challenge, we introduce COVID-Net CT-S, a suite of deep convolutional neural networks for predicting lung disease severity due to COVID-19 infection. More specifically, a 3D residual architecture design is leveraged to learn volumetric visual indicators characterizing the degree of COVID-19 lung disease severity. Experimental results using the patient cohort collected by the China National Center for Bioinformation (CNCB) showed that the proposed COVID-Net CT-S networks, by leveraging volumetric features, can achieve significantly improved severity assessment performance when compared to traditional severity assessment networks that learn and leverage 2D visual features to characterize COVID-19 severity.
112 - Haibo Qi , Yuhan Wang , Xinyu Liu 2021
In this paper, a 3D-RegNet-based neural network is proposed for diagnosing the physical condition of patients with coronavirus (Covid-19) infection. In the application of clinical medicine, lung CT images are utilized by practitioners to determine whether a patient is infected with coronavirus. However, there are some laybacks can be considered regarding to this diagnostic method, such as time consuming and low accuracy. As a relatively large organ of human body, important spatial features would be lost if the lungs were diagnosed utilizing two dimensional slice image. Therefore, in this paper, a deep learning model with 3D image was designed. The 3D image as input data was comprised of two-dimensional pulmonary image sequence and from which relevant coronavirus infection 3D features were extracted and classified. The results show that the test set of the 3D model, the result: f1 score of 0.8379 and AUC value of 0.8807 have been achieved.
With a Coronavirus disease (COVID-19) case count exceeding 10 million worldwide, there is an increased need for a diagnostic capability. The main variables in increasing diagnostic capability are reduced cost, turnaround or diagnosis time, and upfront equipment cost and accessibility. Two candidates for machine learning COVID-19 diagnosis are Computed Tomography (CT) scans and plain chest X-rays. While CT scans score higher in sensitivity, they have a higher cost, maintenance requirement, and turnaround time as compared to plain chest X-rays. The use of portable chest X-radiograph (CXR) is recommended by the American College of Radiology (ACR) since using CT places a massive burden on radiology services. Therefore, X-ray imagery paired with machine learning techniques is proposed a first-line triage tool for COVID-19 diagnostics. In this paper we propose a computer-aided diagnosis (CAD) to accurately classify chest X-ray scans of COVID-19 and normal subjects by fine-tuning several neural networks (ResNet18, ResNet50, DenseNet201) pre-trained on the ImageNet dataset. These neural networks are fused in a parallel architecture and the voting criteria are applied in the final classification decision between the candidate object classes where the output of each neural network is representing a single vote. Several experiments are conducted on the weakly labeled COVID-19-CT-CXR dataset consisting of 263 COVID-19 CXR images extracted from PubMed Central Open Access subsets combined with 25 normal classification CXR images. These experiments show an optimistic result and a capability of the proposed model to outperforming many state-of-the-art algorithms on several measures. Using k-fold cross-validation and a bagging classifier ensemble, we achieve an accuracy of 99.7% and a sensitivity of 100%.
3D CT-scan base on chest is one of the controversial topisc of the researcher nowadays. There are many tasks to diagnose the disease through CT-scan images, include Covid19. In this paper, we propose a method that custom and combine Deep Neural Network to classify the series of 3D CT-scans chest images. In our methods, we experiment with 2 backbones is DenseNet 121 and ResNet 101. In this proposal, we separate the experiment into 2 tasks, one is for 2 backbones combination of ResNet and DenseNet, one is for DenseNet backbones combination.

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