We propose a protocol for generating generalized GHZ states using ultracold fermions in 3D optical lattices or optical tweezer arrays. The protocol uses the interplay between laser driving, onsite interactions and external trapping confinement to enforce energetic spin- and position-dependent constraints on the atomic motion. These constraints allow us to transform a local superposition into a GHZ state through a stepwise protocol that flips one site at a time. The protocol requires no site-resolved drives or spin-dependent potentials, exhibits robustness to slow global laser phase drift, and naturally makes use of the harmonic trap that would normally cause difficulties for entanglement-generating protocols in optical lattices. We also discuss an improved protocol that can compensate for holes in the loadout at the cost of increased generation time. The state can immediately be used for quantum-enhanced metrology in 3D optical lattice clocks, opening a window to push the sensitivity of state-of-the-art sensors beyond the standard quantum limit.
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