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Register a new userValidation of image-guided cochlear implant programming techniques
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Cochlear implants (CIs) are a standard treatment for patients who experience severe to profound hearing loss. Recent studies have shown that hearing outcome is correlated with intra-cochlear anatomy and electrode placement. Our group has developed image-guided CI programming (IGCIP) techniques that use image analysis methods to both segment the inner ear structures in pre- or post-implantation CT images and localize the CI electrodes in post-implantation CT images. This permits to assist audiologists with CI programming by suggesting which among the contacts should be deactivated to reduce electrode interaction that is known to affect outcomes. Clinical studies have shown that IGCIP can improve hearing outcomes for CI recipients. However, the sensitivity of IGCIP with respect to the accuracy of the two major steps: electrode localization and intra-cochlear anatomy segmentation, is unknown. In this article, we create a ground truth dataset with conventional CT and micro-CT images of 35 temporal bone specimens to both rigorously characterize the accuracy of these two steps and assess how inaccuracies in these steps affect the overall results. Our study results show that when clinical pre- and post-implantation CTs are available, IGCIP produces results that are comparable to those obtained with the corresponding ground truth in 86.7% of the subjects tested. When only post-implantation CTs are available, this number is 83.3%. These results suggest that our current method is robust to errors in segmentation and localization but also that it can be improved upon. Keywords: cochlear implant, ground truth, segmentation, validation
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The goals of this dissertation are to fully automate the image processing techniques needed in the post-operative stage of IGCIP and to perform a thorough analysis of (a) the robustness of the automatic image processing techniques used in IGCIP and (b) assess the sensitivity of the IGCIP process as a whole to individual components. The automatic methods that have been developed include the automatic localization of both closely- and distantly-spaced CI electrode arrays in post-implantation CTs and the automatic selection of electrode configurations based on the stimulation patterns. Together with the existing automatic techniques developed for IGCIP, the proposed automatic methods enable an end-to-end IGCIP process that takes pre- and post-implantation CT images as input and produces a patient-customized electrode configuration as output.
Attempts to develop speech enhancement algorithms with improved speech intelligibility for cochlear implant (CI) users have met with limited success. To improve speech enhancement methods for CI users, we propose to perform speech enhancement in a cochlear filter-bank feature space, a feature-set specifically designed for CI users based on CI auditory stimuli. We leverage a convolutional neural network (CNN) to extract both stationary and non-stationary components of environmental acoustics and speech. We propose three CNN architectures: (1) vanilla CNN that directly generates the enhanced signal; (2) spectral-subtraction-style CNN (SS-CNN) that first predicts noise and then generates the enhanced signal by subtracting noise from the noisy signal; (3) Wiener-style CNN (Wiener-CNN) that generates an optimal mask for suppressing noise. An important problem of the proposed networks is that they introduce considerable delays, which limits their real-time application for CI users. To address this, this study also considers causal variations of these networks. Our experiments show that the proposed networks (both causal and non-causal forms) achieve significant improvement over existing baseline systems. We also found that causal Wiener-CNN outperforms other networks, and leads to the best overall envelope coefficient measure (ECM). The proposed algorithms represent a viable option for implementation on the CCi-MOBILE research platform as a pre-processor for CI users in naturalistic environments.
Speech perception is key to verbal communication. For people with hearing loss, the capability to recognize speech is restricted, particularly in a noisy environment or the situations without visual cues, such as lip-reading unavailable via phone call. This study aimed to understand the improvement of vocoded speech intelligibility in cochlear implant (CI) simulation through two potential methods: Speech Enhancement (SE) and Audiovisual Integration. A fully convolutional neural network (FCN) using an intelligibility-oriented objective function was recently proposed and proven to effectively facilitate the speech intelligibility as an advanced denoising SE approach. Furthermore, audiovisual integration is reported to supply better speech comprehension compared to audio-only information. An experiment was designed to test speech intelligibility using tone-vocoded speech in CI simulation with a group of normal-hearing listeners. Experimental results confirmed the effectiveness of the FCN-based denoising SE and audiovisual integration on vocoded speech. Also, it positively recommended that these two methods could become a blended feature in a CI processor to improve the speech intelligibility for CI users under noisy conditions.
Diffusion-weighted magnetic resonance imaging (dMRI) allows non-invasive investigation of whole-brain connectivity, which can potentially help to reveal the brains global network architecture and abnormalities involved in neurological and mental disorders. However, the reliability of connection inferences from dMRI-based fiber tracking is still debated, due to low sensitivity, dominance of false positives, and inaccurate and incomplete reconstruction of long-range connections. Furthermore, parameters of tracking algorithms are typically tuned in a heuristic way, which leaves room for manipulation of an intended result. Here we propose a data-driven framework to optimize and validate parameters of dMRI-based fiber-tracking algorithms using neural tracer data as a reference. Japans Brain/MINDS Project provides invaluable datasets containing both dMRI and neural tracer data from the same primates. We considered four criteria for goodness of fiber tracking: distance-weighted coverage, true/false positive ratio, projection coincidence, and commissural passage, applied using a multi-objective optimization algorithm. We implemented a variant of non-dominated sorting genetic algorithm II (NSGA-II) to optimize five major parameters of a global fiber-tracking algorithm over multiple brain samples in parallel. Using optimized parameters compared to the default parameters, dMRI-based fiber tracking performance was significantly improved, while minimizing false positives and impossible cross-hemisphere connections. Parameters optimized for 10 tracer injection sites showed good generalization capability for other brain samples. These results demonstrate the importance of data-driven adjustment of fiber-tracking algorithms and support the validity of dMRI-based tractography, if appropriate adjustments are employed.
Systematic validation is an essential part of algorithm development. The enormous dataset sizes and the complexity observed in many recent time-resolved 3D fluorescence microscopy imaging experiments, however, prohibit a comprehensive manual ground truth generation. Moreover, existing simulated benchmarks in this field are often too simple or too specialized to sufficiently validate the observed image analysis problems. We present a new semi-synthetic approach to generate realistic 3D+t benchmarks that combines challenging cellular movement dynamics of real embryos with simulated fluorescent nuclei and artificial image distortions including various parametrizable options like cell numbers, acquisition deficiencies or multiview simulations. We successfully applied the approach to simulate the development of a zebrafish embryo with thousands of cells over 14 hours of its early existence.
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