Holographic mutual and tripartite information have been studied in a non-conformal background. We have investigated how these observables behave as the energy scale and number of degrees of freedom vary. We have found out that the effect of degrees of freedom and energy scale is opposite. Moreover, it has been observed that the disentangling transition occurs at large distance between sub-systems in non-conformal field theory independent of l. The mutual information in a non-conformal background remains also monogamous.