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Register a new userLook, Investigate, and Classify: A Deep Hybrid Attention Method for Breast Cancer Classification
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Added by
Bolei Xu
Publication date
2019
fields
Informatics Engineering
and research's language is
English
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One issue with computer based histopathology image analysis is that the size of the raw image is usually very large. Taking the raw image as input to the deep learning model would be computationally expensive while resizing the raw image to low resolution would incur information loss. In this paper, we present a novel deep hybrid attention approach to breast cancer classification. It first adaptively selects a sequence of coarse regions from the raw image by a hard visual attention algorithm, and then for each such region it is able to investigate the abnormal parts based on a soft-attention mechanism. A recurrent network is then built to make decisions to classify the image region and also to predict the location of the image region to be investigated at the next time step. As the region selection process is non-differentiable, we optimize the whole network through a reinforcement approach to learn an optimal policy to classify the regions. Based on this novel Look, Investigate and Classify approach, we only need to process a fraction of the pixels in the raw image resulting in significant saving in computational resources without sacrificing performances. Our approach is evaluated on a public breast cancer histopathology database, where it demonstrates superior performance to the state-of-the-art deep learning approaches, achieving around 96% classification accuracy while only 15% of raw pixels are used.
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Breast cancer is the malignant tumor that causes the highest number of cancer deaths in females. Digital mammograms (DM or 2D mammogram) and digital breast tomosynthesis (DBT or 3D mammogram) are the two types of mammography imagery that are used in clinical practice for breast cancer detection and diagnosis. Radiologists usually read both imaging modalities in combination; however, existing computer-aided diagnosis tools are designed using only one imaging modality. Inspired by clinical practice, we propose an innovative convolutional neural network (CNN) architecture for breast cancer classification, which uses both 2D and 3D mammograms, simultaneously. Our experiment shows that the proposed method significantly improves the performance of breast cancer classification. By assembling three CNN classifiers, the proposed model achieves 0.97 AUC, which is 34.72% higher than the methods using only one imaging modality.
Breast cancer is one of the leading fatal disease worldwide with high risk control if early discovered. Conventional method for breast screening is x-ray mammography, which is known to be challenging for early detection of cancer lesions. The dense breast structure produced due to the compression process during imaging lead to difficulties to recognize small size abnormalities. Also, inter- and intra-variations of breast tissues lead to significant difficulties to achieve high diagnosis accuracy using hand-crafted features. Deep learning is an emerging machine learning technology that requires a relatively high computation power. Yet, it proved to be very effective in several difficult tasks that requires decision making at the level of human intelligence. In this paper, we develop a new network architecture inspired by the U-net structure that can be used for effective and early detection of breast cancer. Results indicate a high rate of sensitivity and specificity that indicate potential usefulness of the proposed approach in clinical use.
Background and Aim: Recently, deep learning using convolutional neural network has been used successfully to classify the images of breast cells accurately. However, the accuracy of manual classification of those histopathological images is comparatively low. This research aims to increase the accuracy of the classification of breast cancer images by utilizing a Patch-Based Classifier (PBC) along with deep learning architecture. Methodology: The proposed system consists of a Deep Convolutional Neural Network (DCNN) that helps in enhancing and increasing the accuracy of the classification process. This is done by the use of the Patch-based Classifier (PBC). CNN has completely different layers where images are first fed through convolutional layers using hyperbolic tangent function together with the max-pooling layer, drop out layers, and SoftMax function for classification. Further, the output obtained is fed to a patch-based classifier that consists of patch-wise classification output followed by majority voting. Results: The results are obtained throughout the classification stage for breast cancer images that are collected from breast-histology datasets. The proposed solution improves the accuracy of classification whether or not the images had normal, benign, in-situ, or invasive carcinoma from 87% to 94% with a decrease in processing time from 0.45 s to 0.2s on average. Conclusion: The proposed solution focused on increasing the accuracy of classifying cancer in the breast by enhancing the image contrast and reducing the vanishing gradient. Finally, this solution for the implementation of the Contrast Limited Adaptive Histogram Equalization (CLAHE) technique and modified tangent function helps in increasing the accuracy.
Purpose: To determine whether deep learning models can distinguish between breast cancer molecular subtypes based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Materials and methods: In this institutional review board-approved single-center study, we analyzed DCE-MR images of 270 patients at our institution. Lesions of interest were identified by radiologists. The task was to automatically determine whether the tumor is of the Luminal A subtype or of another subtype based on the MR image patches representing the tumor. Three different deep learning approaches were used to classify the tumor according to their molecular subtypes: learning from scratch where only tumor patches were used for training, transfer learning where networks pre-trained on natural images were fine-tuned using tumor patches, and off-the-shelf deep features where the features extracted by neural networks trained on natural images were used for classification with a support vector machine. Network architectures utilized in our experiments were GoogleNet, VGG, and CIFAR. We used 10-fold crossvalidation method for validation and area under the receiver operating characteristic (AUC) as the measure of performance. Results: The best AUC performance for distinguishing molecular subtypes was 0.65 (95% CI:[0.57,0.71]) and was achieved by the off-the-shelf deep features approach. The highest AUC performance for training from scratch was 0.58 (95% CI:[0.51,0.64]) and the best AUC performance for transfer learning was 0.60 (95% CI:[0.52,0.65]) respectively. For the off-the-shelf approach, the features extracted from the fully connected layer performed the best. Conclusion: Deep learning may play a role in discovering radiogenomic associations in breast cancer.
Ultrasound image diagnosis of breast tumors has been widely used in recent years. However, there are some problems of it, for instance, poor quality, intense noise and uneven echo distribution, which has created a huge obstacle to diagnosis. To overcome these problems, we propose a novel method, a breast cancer classification with ultrasound images based on SLIC (BCCUI). We first utilize the Region of Interest (ROI) extraction based on Simple Linear Iterative Clustering (SLIC) algorithm and region growing algorithm to extract the ROI at the super-pixel level. Next, the features of ROI are extracted. Furthermore, the Support Vector Machine (SVM) classifier is applied. The calculation states that the accuracy of this segment algorithm is up to 88.00% and the sensitivity of the algorithm is up to 92.05%, which proves that the classifier presents in this paper has certain research meaning and applied worthiness.
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