This paper considers large families of Markov chains (MCs) that are defined over a set of parameters with finite discrete domains. Such families occur in software product lines, planning under partial observability, and sketching of probabilistic programs. Simple questions, like `does at least one family member satisfy a property?, are NP-hard. We tackle two problems: distinguish family members that satisfy a given quantitative property from those that do not, and determine a family member that satisfies the property optimally, i.e., with the highest probability or reward. We show that combining two well-known techniques, MDP model checking and abstraction refinement, mitigates the computational complexity. Experiments on a broad set of benchmarks show that in many situations, our approach is able to handle families of millions of MCs, providing superior scalability compared to existing solutions.