Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userPathological Evidence Exploration in Deep Retinal Image Diagnosis
50
0
0.0
(
0
)
Added by
Yuhao Niu
Publication date
2018
fields
Informatics Engineering
and research's language is
English
Ask ChatGPT about the research
No Arabic abstract
Though deep learning has shown successful performance in classifying the label and severity stage of certain disease, most of them give few evidence on how to make prediction. Here, we propose to exploit the interpretability of deep learning application in medical diagnosis. Inspired by Kochs Postulates, a well-known strategy in medical research to identify the property of pathogen, we define a pathological descriptor that can be extracted from the activated neurons of a diabetic retinopathy detector. To visualize the symptom and feature encoded in this descriptor, we propose a GAN based method to synthesize pathological retinal image given the descriptor and a binary vessel segmentation. Besides, with this descriptor, we can arbitrarily manipulate the position and quantity of lesions. As verified by a panel of 5 licensed ophthalmologists, our synthesized images carry the symptoms that are directly related to diabetic retinopathy diagnosis. The panel survey also shows that our generated images is both qualitatively and quantitatively superior to existing methods.
rate research
Read More
Synthesizing images of the eye fundus is a challenging task that has been previously approached by formulating complex models of the anatomy of the eye. New images can then be generated by sampling a suitable parameter space. In this work, we propose a method that learns to synthesize eye fundus images directly from data. For that, we pair true eye fundus images with their respective vessel trees, by means of a vessel segmentation technique. These pairs are then used to learn a mapping from a binary vessel tree to a new retinal image. For this purpose, we use a recent image-to-image translation technique, based on the idea of adversarial learning. Experimental results show that the original and the generated images are visually different in terms of their global appearance, in spite of sharing the same vessel tree. Additionally, a quantitative quality analysis of the synthetic retinal images confirms that the produced images retain a high proportion of the true image set quality.
Retinal image quality assessment is an essential prerequisite for diagnosis of retinal diseases. Its goal is to identify retinal images in which anatomic structures and lesions attracting ophthalmologists attention most are exhibited clearly and definitely while reject poor quality fundus images. Motivated by this, we mimic the way that ophthalmologists assess the quality of retinal images and propose a method termed SalStructuIQA. First, two salient structures for automated retinal quality assessment. One is the large-size salient structures including optic disc region and exudates in large-size. The other is the tiny-size salient structures which mainly include vessels. Then we incorporate the proposed two salient structure priors with deep convolutional neural network (CNN) to shift the focus of CNN to salient structures. Accordingly, we develop two CNN architectures: Dual-branch SalStructIQA and Single-branch SalStructIQA. Dual-branch SalStructIQA contains two CNN branches and one is guided by large-size salient structures while the other is guided by tiny-size salient structures. Single-branch SalStructIQA contains one CNN branch, which is guided by the concatenation of salient structures in both large-size and tiny-size. Experimental results on Eye-Quality dataset show that our proposed Dual-branch SalStructIQA outperforms the state-of-the-art methods for retinal image quality assessment and Single-branch SalStructIQA is much light-weight comparing with state-of-the-art deep retinal image quality assessment methods and still achieves competitive performances.
Automatically generating medical reports for retinal images is one of the promising ways to help ophthalmologists reduce their workload and improve work efficiency. In this work, we propose a new context-driven encoding network to automatically generate medical reports for retinal images. The proposed model is mainly composed of a multi-modal input encoder and a fused-feature decoder. Our experimental results show that our proposed method is capable of effectively leveraging the interactive information between the input image and context, i.e., keywords in our case. The proposed method creates more accurate and meaningful reports for retinal images than baseline models and achieves state-of-the-art performance. This performance is shown in several commonly used metrics for the medical report generation task: BLEU-avg (+16%), CIDEr (+10.2%), and ROUGE (+8.6%).
The identification of Alzheimers disease (AD) and its early stages using structural magnetic resonance imaging (MRI) has been attracting the attention of researchers. Various data-driven approaches have been introduced to capture subtle and local morphological changes of the brain accompanied by the disease progression. One of the typical approaches for capturing subtle changes is patch-level feature representation. However, the predetermined regions to extract patches can limit classification performance by interrupting the exploration of potential biomarkers. In addition, the existing patch-level analyses have difficulty explaining their decision-making. To address these problems, we propose the BrainBagNet with a position-based gate (PG-BrainBagNet), a framework for jointly learning pathological region localization and AD diagnosis in an end-to-end manner. In advance, as all scans are aligned to a template in image processing, the position of brain images can be represented through the 3D Cartesian space shared by the overall MRI scans. The proposed method represents the patch-level response from whole-brain MRI scans and discriminative brain-region from position information. Based on the outcomes, the patch-level class evidence is calculated, and then the image-level prediction is inferred by a transparent aggregation. The proposed models were evaluated on the ADNI datasets. In five-fold cross-validation, the classification performance of the proposed method outperformed that of the state-of-the-art methods in both AD diagnosis (AD vs. normal control) and mild cognitive impairment (MCI) conversion prediction (progressive MCI vs. stable MCI) tasks. In addition, changes in the identified discriminant regions and patch-level class evidence according to the patch size used for model training are presented and analyzed.
The spatial distributions of different types of cells could reveal a cancer cell growth pattern, its relationships with the tumor microenvironment and the immune response of the body, all of which represent key hallmarks of cancer. However, manually recognizing and localizing all the cells in pathology slides are almost impossible. In this study, we developed an automated cell type classification pipeline, ConvPath, which includes nuclei segmentation, convolutional neural network-based tumor, stromal and lymphocytes classification, and extraction of tumor microenvironment related features for lung cancer pathology images. The overall classification accuracy is 92.9% and 90.1% in training and independent testing datasets, respectively. By identifying cells and classifying cell types, this pipeline can convert a pathology image into a spatial map of tumor, stromal and lymphocyte cells. From this spatial map, we can extracted features that characterize the tumor micro-environment. Based on these features, we developed an image feature-based prognostic model and validated the model in two independent cohorts. The predicted risk group serves as an independent prognostic factor, after adjusting for clinical variables that include age, gender, smoking status, and stage.
suggested questions
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
