We develop an iterative method for constructing four-dimensional generalized unitarity cuts in $mathcal{N} = 2$ supersymmetric Yang-Mills (SYM) theory coupled to fundamental matter hypermultiplets ($mathcal{N} = 2$ SQCD). For iterated two-particle cuts,specifically those involving only four-point amplitudes, this implies simple diagrammatic rules for assembling the cuts to any loop order, reminiscent of the rung rule in $mathcal{N} = 4$ SYM. By identifying physical poles, the construction simplifies the task of extracting complete integrands. In combination with the duality between color and kinematics we construct all four-point massless MHV-sector scattering amplitudes up to two loops in $mathcal{N} = 2$ SQCD, including those with matter on external legs. Our results reveal chiral infrared-finite integrands closely related to those found using loop-level BCFW recursion. The integrands are valid in $Dleq 6$ dimensions with external states in a four-dimensional subspace; the upper bound is dictated by our use of six-dimensional chiral $mathcal{N} = (1,0)$ SYM as a means of dimensionally regulating loop integrals.
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